Structural Studies of Synthetic Hormones and Polypeptides

发展一种系统和合理的方法来理解肽激素和神经递质传递信息的基本物理和化学原理是科学中的一个基本问题。细胞间通信是生命的核心，对通信系统的理解对于进一步理解生命过程以及它们如何被控制和调节是必要的。Hruby博士在过去几年中一直在开发的方法已经导致具有独特生物活性的肽激素和神经递质。他正在继续发展构象和拓扑结构与肽激素和神经递质生物活性的各个方面的关系。特别是那些定义和区分受体识别和结合，信息转导和延长受体相关的生物活性的特征将被研究。那些具有有趣或独特的生物学特性或特定构象特征的肽将通过NMR， CD和其他生物物理方法进行检查，以特定地了解其构象和动态特性。

Developing a systematic and rational approach to an understanding of the underlying physical and chemical principles involved in information transfer by peptide hormones and neurotransmitters is a fundamental problem in science. Intercellular communication is central to life and an understanding of the systems involved in communication is necessary for further understanding oflife processes and how they might be controlled and modulated. The approach Dr. Hruby has been developing over the past several years has led to peptide hormones and neurotransmitters with unique biological activities. He is continuing to develop the relationships of conformation and topology to various aspects of peptide hormone and neurotransmitter biological activity. In particular, those features which define and distinguish receptor recognition and binding, transduction of information and prolonged receptor- related biological activity will be studied. Those peptides with interesting or unique biological properties or specific conformational features will be examined by NMR, CD and other biophysical methods for specific insight into their conformational and dynamic properties.