Structural Studies of Synthetic Hormones and Polypeptides

制定一个系统和合理的方法， 了解潜在的物理和化学 肽的信息传递原理 激素和神经递质是一种基本的 科学中的问题。 细胞间通讯是 生活和理解的系统所涉及的 交流对于进一步了解生命是必要的 过程以及如何控制和调节它们。 的 Hruby博士在过去几年中开发的方法 多年来，导致肽激素和神经递质， 独特的生物活性。 他继续发展构象的关系 和拓扑结构的肽激素的各个方面， 神经递质生物活性。 特别是那些 定义和区分受体识别的特征， 结合，信息传递和延长受体- 将研究相关的生物活性。 那些肽 具有有趣或独特的生物学特性或特定的 构象特征将通过NMR、CD和其他方法进行检查。 生物物理方法，以具体了解其 构象和动力学性质。

Developing a systematic and rational approach to an understanding of the underlying physical and chemical principles involved in information transfer by peptide hormones and neurotransmitters is a fundamental problem in science. Intercellular communication is central to life and an understanding of the systems involved in communication is necessary for further understanding oflife processes and how they might be controlled and modulated. The approach Dr. Hruby has been developing over the past several years has led to peptide hormones and neurotransmitters with unique biological activities. He is continuing to develop the relationships of conformation and topology to various aspects of peptide hormone and neurotransmitter biological activity. In particular, those features which define and distinguish receptor recognition and binding, transduction of information and prolonged receptor- related biological activity will be studied. Those peptides with interesting or unique biological properties or specific conformational features will be examined by NMR, CD and other biophysical methods for specific insight into their conformational and dynamic properties.