Structural Studies of Synthetic Hormones and Polypeptides

发展一种系统和合理的方法来理解多肽、激素和神经递质传递信息所涉及的基本物理和化学原理，是科学中的一个基本问题。细胞间通信是生命的核心，了解参与通信的系统对于进一步了解生命过程以及如何控制和调节这些过程是必要的。赫鲁比博士在过去几年里一直在开发的方法导致了具有独特生物学活性的多肽激素和神经递质。他正在继续发展构象和拓扑与多肽、激素和神经递质生物活性的各个方面的关系。特别是，那些定义和区分受体识别和结合、信息转导和延长与受体相关的生物活性的特征将被研究。那些具有有趣的或独特的生物学性质或特定构象特征的多肽将通过核磁共振、CD和其他生物物理方法进行研究，以具体了解它们的构象和动力学性质。

Developing a systematic and rational approach to an understanding of the underlying physical and chemical principles involved in information transfer by peptide hormones and neurotransmitters is a fundamental problem in science. Intercellular communication is central to life and an understanding of the systems involved in communication is necessary for further understanding oflife processes and how they might be controlled and modulated. The approach Dr. Hruby has been developing over the past several years has led to peptide hormones and neurotransmitters with unique biological activities. He is continuing to develop the relationships of conformation and topology to various aspects of peptide hormone and neurotransmitter biological activity. In particular, those features which define and distinguish receptor recognition and binding, transduction of information and prolonged receptor- related biological activity will be studied. Those peptides with interesting or unique biological properties or specific conformational features will be examined by NMR, CD and other biophysical methods for specific insight into their conformational and dynamic properties.