U.S.-Hungary Cooperative Research: Conformational Analysis of Biologically Active Peptides and Proteins in Solution and Gas Phases

美国-匈牙利合作研究：溶液和气相中生物活性肽和蛋白质的构象分析

• 批准号: 0122172
• 负责人: Victor Hruby
• 金额: $ 2.84万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-15 至 2005-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0122172&HistoricalAwards=false
• 关键词: U.S.; Hungary; Cooperative; Research; Conformational

This U.S.-Hungary research project between Victor Hruby of the University of Arizona and Katalin Kover of the University of Debrecen features the study of bioactive peptide function. Specifically, conformations and dynamics of oligopeptides, peptide mimetics, proteins and peptide protein complexes in both the solution and gas phases will be examined using multi-dimensional NMR, tandem mass spectrometry and theoretical methods. The researchers intend to examine the role of three-dimensional structures and molecular dynamics in the biological activity of peptides and proteins with the goal of better understanding the behavior of synthetic oligopeptides, proteins and peptide-protein complexes. If successful, results may yield new information leading to the definition of peptidomimetic compounds that are potentially useful as reagents or in drug development.This biophysics research project fulfills the program objective of advancing scientific knowledge by enabling experts in the United States and Central Europe to combine complementary talents and share research resources inn areas of strong mutual interest and competence.

亚利桑那大学的维克多·赫鲁比和德布勒森大学的卡塔林·科弗开展了这项美国-匈牙利合作研究项目，研究生物活性多肽的功能。具体地说，将利用多维核磁共振、串联质谱学和理论方法研究低聚肽、多肽模拟物、蛋白质和多肽蛋白质复合体在溶液和气相中的构象和动力学。研究人员打算研究三维结构和分子动力学在多肽和蛋白质生物活性中的作用，目的是更好地了解合成寡肽、蛋白质和多肽-蛋白质复合体的行为。如果成功，结果可能会产生新的信息，导致对可能用作试剂或药物开发的肽仿制化合物的定义。这一生物物理学研究项目通过使美国和中欧的专家能够结合互补的人才并在相互感兴趣和能力很强的领域共享研究资源，实现了促进科学知识的计划目标。