U.S.-Hungary Cooperative Research: Conformational Analysis of Biologically Active Peptides and Proteins in Solution and Gas Phases

美国-匈牙利合作研究：溶液和气相中生物活性肽和蛋白质的构象分析

• 批准号: 0122172
• 负责人: Victor Hruby
• 金额: $ 2.84万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-15 至 2005-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0122172&HistoricalAwards=false
• 关键词: U.S.; Hungary; Cooperative; Research; Conformational

This U.S.-Hungary research project between Victor Hruby of the University of Arizona and Katalin Kover of the University of Debrecen features the study of bioactive peptide function. Specifically, conformations and dynamics of oligopeptides, peptide mimetics, proteins and peptide protein complexes in both the solution and gas phases will be examined using multi-dimensional NMR, tandem mass spectrometry and theoretical methods. The researchers intend to examine the role of three-dimensional structures and molecular dynamics in the biological activity of peptides and proteins with the goal of better understanding the behavior of synthetic oligopeptides, proteins and peptide-protein complexes. If successful, results may yield new information leading to the definition of peptidomimetic compounds that are potentially useful as reagents or in drug development.This biophysics research project fulfills the program objective of advancing scientific knowledge by enabling experts in the United States and Central Europe to combine complementary talents and share research resources inn areas of strong mutual interest and competence.

亚利桑那大学的维克多·赫鲁比（Victor Hruby）与碎片大学的Katalin Kover之间的这项美国 - 匈牙利研究项目具有生物活性肽功能的研究。 具体而言，将使用多维NMR，串联质谱法和理论方法研究溶液和气相中寡肽，肽模拟物，蛋白质和肽蛋白复合物的构象和动力学。研究人员打算检查三维结构和分子动力学在肽和蛋白质的生物学活性中的作用，以更好地了解合成寡肽，蛋白质和肽蛋白复合物的行为。 如果成功，结果可能会产生新的信息，从而导致肽型化合物的定义，这些化合物可能是试剂或药物开发中有用的。本生物物理学研究项目实现了通过使美国和中欧的专家结合互补才能并共享强大的共同利益和竞争力的研究资源来推进科学知识的计划目标。