Coupled Heat and Mass Transfer During Tissue Freezing

组织冷冻过程中的热质耦合传递

• 批准号: 8713600
• 负责人: Kenneth Diller
• 金额: $ 28.44万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1991-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8713600&HistoricalAwards=false
• 关键词: Coupled; Heat; Mass; Transfer; During

The objective of this research is to obtain significant new knowledge about the heat and mass transfer processes involved in the freezing of living cells and to relate this knowledge to cryopreservation procedures. Experimental and modeling techniques will be used in a complementary manner to provide a bridge microscopic and macroscopic scale phenomena that govern practical cell freezing procedures. Up to now most of the development work on cryopreservation processes has been empirical in nature, and many crucial problems have remained partially or totally unsolved. The present research will remedy this situation by studying the complex, coupled interactions among the thermal, osmotic, and physiological parameters which govern the freezing of living tissue. Furthermore, research will address the cryopreservation of a number of types of tissue of large commercial significance, including human skin and mammalian embryos.

这项研究的目的是获得重要的新知识 关于冻结过程中涉及的热量和质量传递过程， 活细胞并将这些知识与冷冻保存联系起来 程序. 实验和建模技术将用于 以互补的方式提供微观和宏观的桥梁 控制实际细胞冷冻程序的结垢现象。 到目前为止，大多数关于低温保存方法的开发工作都是在 在本质上是经验主义的，许多关键问题仍然存在， 部分或全部未解决。 目前的研究将弥补这一点 通过研究复杂的，耦合的相互作用， 控制冷冻的温度、渗透压和生理参数 活体组织 此外，研究将解决 冷冻保存的一些类型的大型商业组织 重要性，包括人类皮肤和哺乳动物胚胎。