Conference on Organization of the Bacterial Chromosome; May 23-26, 1988; Pine Mountain, GA

细菌基因组的组织和结构是一个广泛的主题，微生物分子生物学的许多领域应用于该主题的几个方面。来自分子生物学或细菌遗传学不同领域的研究人员对细菌基因组作为一个整体有共同的兴趣，他们的兴趣源于完全不同的角度，并且倾向于在不重叠的科学轨道上旅行。该提案寻求支持召开一次会议，为这些科学家提供一个机会，让他们聚集在一起，就细菌染色体的组织和功能交换信息和想法。会议将涉及的主题包括细胞内DNA的组织、类核的结构、核蛋白的参与、染色体结构对基因表达的影响、基因组在遗传变化方面的可塑性、对这种变化的限制的存在、对整体细胞功能的控制、综述了基因图谱、物理图谱、核苷酸和氨基酸序列组装的进展，并提出了实现有效数据管理的问题和解决方案。迄今为止还没有举行过这种会议；它似乎具有很大的潜力，可以在研究方向很少交叉的科学家之间，以及在从事有关细菌染色体结构和功能的类似问题的科学家之间，产生新的知识交流。

Organization and structure of the bacterial genome is a broad subject, with many areas of microbial molecular biology applying to several aspects of the subject. Researchers from different areas of molecular biology or bacterial genetics who share an interest in the bacterial genome viewed as a whole have interests that stem from quite different perspectives, and tend to travel in non-overlapping scientific orbits. This proposal seeks support for a conference that would provide an opportunity for such scientists to get together and exchange information and ideas on the organization and function of the bacterial chromosome. Subjects to be covered at the meeting would include the organization of DNA in the cell, the structure of the nucleoid, the involvement of nucleoproteins, the effect of chromosomal structure on gene expression, the plasticity of the genome in terms of genetic change, the existence of constraints on such change, the control of global cellular functions, and a summary of the progress made in assembling genetic maps, physical maps and nucleotide and amino acid sequences, together with a consideration of problems and solutions to achieving effective data management. A meeting of this kind has not been held to date; it would seem to have high potential for generating fresh intellectul exchange among scientists whose paths seldom cross, as well as among those who are engaged in asking similar questions about structure and function of the bacterial chromosome.