Third E. coli Genome Meeting: November 4-8, 1994 at Woods Hole, MA

为了整合大肠杆菌基因组的信息，在不同领域研究大肠杆菌的科学家将会面。测序者、克隆者、遗传学家、细胞生理学家、生物化学家、数据库建设者和计算机科学家都来自不同的视角，现在正在融合在一起。本次会议将汇集基因组分析的主要研究人员，在遗传和序列水平上促进必要的互动，并将促进该生物基因组结构和功能分析的协调。大肠杆菌基因组分析工作很可能是第一个实现自由生物的完整序列测定的工作。在撰写本文时，已对2000多个基因和开放阅读框进行了测序，超过55%的染色体DNA及其鉴定的基因产物已在瑞士蛋白质数据库中。大肠杆菌广泛的遗传、生理和生化知识使其成为所有生物体中定义最好的。当我们接近大肠杆菌DNA和所有基因产物的总序列时，现在有很多令人兴奋的前所未有的机会来整合这些信息体。＊＊＊

9405561 Riley To carry out integration of information on the genome of the bacterium E. coli scientists working on E. coli in different areas will meet. The sequencers, cloners, geneticists, cell physiologists, biochemists, database builders and computer scientists all come from different perspectives that are now fusing. This meeting will facilitate the necessary interactions by bringing together leading researchers in the analysis of genomes at the genetic and sequence level, and will facilitate the coordination of the structural and functional analysis of this organism's genome. %%% The E. coli genome analysis efforts are likely to be the first which will achieve a complete sequence determination of a free-living organism. At this writing over 2000 genes and open reading frames have been sequenced, over 55% of the chromosomal DNA, and their gene products where identified are in the Swiss Protein database. The extensive genetic, physiological and biochemical knowledge of E. coli make this the best defined of all organisms. There is much excitement surrounding the unprecedented opportunity now to integrate these bodies of information as we approach total sequence E. coli DNA and all gene products. ***