Calcium Channels: NYAS Conference; on July 18-20, 1988, London, England.

钙通道：NYAS 会议；

• 批准号: 8719443
• 负责人: Peter Hess
• 金额: $ 0.5万
• 依托单位: New York Academy of Sciences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-05-01 至 1989-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8719443&HistoricalAwards=false
• 关键词: Calcium; Channels; NYAS; Conference; July

This conference sponsored by the New York Academy of Sciences will highlight the remarkable progress achieved over the last few years concerning calcium channels in excitable tissues. Advances were mainly possible because of the development of new Ca++ channel ligands and of new methods for the detailed functional investigation of single Ca++ channel molecules. Thus, several distinct Ca++ channel types with different biophysical, physiological, pharmacological and regulatory properties have been identified. New models for the mechanisms of ion permeation and channel gating have been developed. New high-affinity ligands have allowed the chemical purification and elucidation of the subunit composition of at least one channel type, the localization of channel distribution as well as the observation of Ca++ channel expression during development and in various diseases. Additionally, antibodies against Ca++ channels have been implicated in the pathogenesis of Lambert-Eaton Myasthenic Syndrome, and a specific absence of Ca++ channels has been demonstrated in muscular dysgenesis. Ca++ channel study has evolved into a truly multi-disciplinary effort. The conference will bring together scientists from neurobiology, biochemistry, molecular biology, physiology and pharmacology, each contributing a vital part to the understanding of this relevant biological signalling pathway.

这次会议由纽约科学院主办 将强调过去几年取得的显著进展， 多年来关于兴奋性组织中的钙通道。 进展 主要是因为新的Ca++的发展， 通道配体和新方法的详细功能 单个Ca++通道分子的研究。 因此， 不同的Ca++通道类型具有不同的生物物理特性， 生理学、药理学和调节特性具有 被识别。 离子渗透机理的新模型 和通道选通。 新型高亲和力 配体允许化学纯化和阐明 至少一种通道类型的亚基组成， 渠道分布的本地化以及观察 发育过程中和各种组织中Ca++通道表达的变化 疾病 此外，针对Ca++通道的抗体具有 与Lambert-Eaton肌无力症的发病机制有关 综合征，和一个特定的缺乏钙++通道已被 表现为肌肉发育不全。 Ca++通道研究 演变成一个真正的多学科的努力。 会议 将汇集神经生物学、生物化学、 分子生物学、生理学和药理学， 这是理解这一相关生物学的重要组成部分， 信号通路