Modeling Facility for Molecular Biology

分子生物学建模设施

• 批准号: 8720229
• 负责人: Barry Honig
• 金额: $ 85.24万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8720229&HistoricalAwards=false
• 关键词: Modeling; Facility; Molecular; Biology

This award will provide funds for technical assistance and for equipment useful in structural analysis of various proteins and nucleic acids. The equipment items include computational tools useful for the analysis and interpretation of data obtained through X-ray crystallography and NMR spectroscopy, and other instruments useful in the preparation of samples for analysis by these techniques. The group of investigators who will benefit from the award include internationally known experts in use of these techniques of structural analysis and other, equally respected biologists whose research will benefit greatly from collaboration with the structural experts. The development and application of 2-dimensional NMR spectroscopy and X-ray crystallography to the study of the structure and function of biological macromolecules is currently one of the most exiting areas of biological research. In recent years, rapid progress has been made in the development of computational tools that allow these techniques to be applied to a variety of molecules rather than, as previously, to the few molecules most amenable to such analysis. The simultaneous development of molecular genetic and other, biochemical techniques have also increased the variety and sophistication of the structural questions that can be approached with these techniques. The equipment and technical assistance provided by this award will enable a group of outstanding molecular geneticists to collaborate and to instruct each other in the use of the most recent advances.

该奖项将为技术援助提供资金， 适用于各种蛋白质和核酸结构分析的设备 acids. 这些设备包括可用于 X射线数据的分析和解释 晶体学和核磁共振光谱学，以及其他有用的仪器， 用这些技术制备样品进行分析。 本集团 将从该奖项中受益的调查人员包括 国际知名的专家在使用这些技术的结构 分析和其他同样受人尊敬的生物学家，他们的研究 从与结构专家的合作中受益匪浅。 二维核磁共振波谱技术的发展与应用 和X射线晶体学的结构和功能的研究 生物大分子是目前最具活力的领域之一， 生物学研究 近年来，在以下方面取得了迅速进展： 计算工具的发展，使这些技术， 可以应用于各种分子，而不是像以前那样， 少数分子最适合这样的分析。 同时 分子遗传学和其他生物化学技术的发展， 也增加了结构的多样性和复杂性， 这些问题可以通过这些技术来解决。 设备 该奖项提供的技术援助将使一组 优秀的分子遗传学家合作，并指导每个 另一个是利用最新的进展。