Theoretical Studies of Membrane Proteins

膜蛋白的理论研究

• 批准号: 9304127
• 负责人: Barry Honig
• 金额: $ 61万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9304127&HistoricalAwards=false
• 关键词: Theoretical; Studies; Membrane; Proteins

The DelPhi program will be extended to problems related to membrane protein systems. These studies aim at clarifying the principles that underlie the structure and function of membrane proteins. Membrane protein electrostatic properties will be characterized, free energies of insertion of proteins into the membrane phase will be calculated, and pH effects relevant to the function of membrane proteins will be investigated. %%% Theoretical and computational methods will be employed to characterize the structure of proteins which interact with biological membranes. Initially protein structure will be reduced to a simple electrostatic-geometric model which will be interacted with a membrane bilayer. Such studies will contribute important insights into: the stability of proteins when embedded in biological membranes, the energy required to insert proteins into membranes, and how protein behavior is controlled in membrane systems. Since the membrane: protein system is largely responsible for transferring information from the environment into the cell, understanding the fundamentals of the structure of the protein: membrane system itself is of great importance.

德尔菲程序将扩展到与膜相关的问题 蛋白质系统 这些研究旨在阐明这些原则 构成膜蛋白结构和功能的基础。 膜蛋白的静电特性将被表征， 蛋白质插入膜相的自由能将 pH效应与膜的功能有关 将研究蛋白质。 %%% 将采用理论和计算方法， 表征与蛋白质相互作用的蛋白质的结构 生物膜 最初蛋白质结构将被减少 一个简单的静电几何模型， 具有膜双层。 这些研究将有助于 深入了解：蛋白质嵌入时的稳定性 生物膜，插入蛋白质所需的能量， 以及蛋白质的行为是如何在膜中控制的 系统. 由于膜：蛋白质系统是主要负责 为了将信息从环境传递到细胞中， 了解结构的基本原理， 蛋白质：膜系统本身非常重要。