Theoretical Studies of Membrane Proteins

膜蛋白的理论研究

• 批准号: 9304127
• 负责人: Barry Honig
• 金额: $ 61万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9304127&HistoricalAwards=false
• 关键词: Theoretical; Studies; Membrane; Proteins

The DelPhi program will be extended to problems related to membrane protein systems. These studies aim at clarifying the principles that underlie the structure and function of membrane proteins. Membrane protein electrostatic properties will be characterized, free energies of insertion of proteins into the membrane phase will be calculated, and pH effects relevant to the function of membrane proteins will be investigated. %%% Theoretical and computational methods will be employed to characterize the structure of proteins which interact with biological membranes. Initially protein structure will be reduced to a simple electrostatic-geometric model which will be interacted with a membrane bilayer. Such studies will contribute important insights into: the stability of proteins when embedded in biological membranes, the energy required to insert proteins into membranes, and how protein behavior is controlled in membrane systems. Since the membrane: protein system is largely responsible for transferring information from the environment into the cell, understanding the fundamentals of the structure of the protein: membrane system itself is of great importance.

Delphi计划将扩展到与膜蛋白系统相关的问题。这些研究旨在阐明膜蛋白结构和功能的基本原理。将表征膜蛋白质的静电性质，计算蛋白质插入膜相的自由能，并研究与膜蛋白质功能相关的pH效应。将使用理论和计算方法来表征与生物膜相互作用的蛋白质的结构。首先，蛋白质结构将被简化为一个简单的静电几何模型，该模型将与膜双层相互作用。这些研究将有助于对以下方面的重要见解：蛋白质嵌入生物膜时的稳定性，将蛋白质插入膜中所需的能量，以及膜系统中蛋白质行为是如何控制的。由于膜：蛋白质系统在很大程度上负责将信息从环境传递到细胞中，因此了解蛋白质的基本结构：膜系统本身是非常重要的。