Theoretical Studies of Membrane Proteins
膜蛋白的理论研究
基本信息
- 批准号:9808902
- 负责人:
- 金额:$ 67.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-07-01 至 2004-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
9808902 Honig This project represents the continuation of a research program whose overall objective is to further understanding of the physical principles that determine the structure and function of membrane proteins. Theoretical calculations based primarily on numerical solutions to the Poisson-Boltzmann equation will be used to study important biological processes such as the association of proteins with membrane surfaces, lateral domain formation in lipid bilayers and protein-protein interactions in src family kinases. Electrostatic free energies obtained from the calculations will be used construct testable models which can explain that remarkable localization phenomena that lead to the formation of distinct phases in biological membranes and to the precise recognition of specific protein domains for one another. Subcellular localization is a central feature of many biological phenomena such as viral assembly and signal transduction. At present there is only limited understanding of the processes that underlie these phenomena and their physical-chemical basis is even more poorly understood. The proposed calculations and the related collaborations with experimental groups are intended to fill this existing gap in knowledge by providing detailed atom-level explanations of localization and specificity near membrane surfaces.
[808902] Honig本项目是一个研究项目的延续,其总体目标是进一步了解决定膜蛋白结构和功能的物理原理。理论计算主要基于泊松-玻尔兹曼方程的数值解,将用于研究重要的生物过程,如蛋白质与膜表面的关联,脂质双分子层的侧结构域形成和src家族激酶的蛋白质-蛋白质相互作用。从计算中获得的静电自由能将用于构建可测试的模型,该模型可以解释导致生物膜中形成不同相的显着定位现象,并精确识别彼此的特定蛋白质结构域。亚细胞定位是许多生物现象的中心特征,如病毒组装和信号转导。目前,人们对这些现象背后的过程了解有限,对它们的物理化学基础更是知之甚少。提出的计算和与实验组的相关合作旨在通过提供膜表面附近的定位和特异性的详细原子水平解释来填补这一现有的知识空白。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Barry Honig其他文献
Model-building of neurohypophyseal hormones.
神经垂体激素的模型构建。
- DOI:
- 发表时间:
1973 - 期刊:
- 影响因子:5.6
- 作者:
Barry Honig;Barry Honig;E. A. Kabat;E. A. Kabat;Lou Katz;Lou Katz;Cyrus Levinthal;Cyrus Levinthal;Tai Te Wu;Tai Te Wu - 通讯作者:
Tai Te Wu
Flipping Watson and Crick
颠倒沃森和克里克
- DOI:
10.1038/470472a - 发表时间:
2011-02-23 - 期刊:
- 影响因子:48.500
- 作者:
Barry Honig;Remo Rohs - 通讯作者:
Remo Rohs
Molecular aspects of photoreceptor function
光感受器功能的分子方面
- DOI:
- 发表时间:
1975 - 期刊:
- 影响因子:0
- 作者:
Thomas G. Ebrey;Barry Honig - 通讯作者:
Barry Honig
Flipping Watson and Crick
颠倒沃森和克里克
- DOI:
10.1038/470472a - 发表时间:
2011-02-23 - 期刊:
- 影响因子:48.500
- 作者:
Barry Honig;Remo Rohs - 通讯作者:
Remo Rohs
A Role for Topologically-Inverted Structural Repeats in Secondary Active Transport by Membrane Proteins of the LeuT Fold
- DOI:
10.1016/j.bpj.2008.12.2859 - 发表时间:
2009-02-01 - 期刊:
- 影响因子:
- 作者:
Lucy Forrest;Yuan-Wei Zhang;Barry Honig;Gary Rudnick - 通讯作者:
Gary Rudnick
Barry Honig的其他文献
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{{ truncateString('Barry Honig', 18)}}的其他基金
Collaborative Research: NSF-BSF: How cell adhesion molecules control neuronal circuit wiring: Binding affinities, binding availability and sub-cellular localization
合作研究:NSF-BSF:细胞粘附分子如何控制神经元电路布线:结合亲和力、结合可用性和亚细胞定位
- 批准号:
2321480 - 财政年份:2024
- 资助金额:
$ 67.5万 - 项目类别:
Continuing Grant
Molecular Mechanisms in Adhesion Protein Mediated Neuron-Neuron Recognition
粘附蛋白介导的神经元-神经元识别的分子机制
- 批准号:
1914542 - 财政年份:2019
- 资助金额:
$ 67.5万 - 项目类别:
Standard Grant
The Molecular Basis of Cadherin-Mediated Cell Adhesion
钙粘蛋白介导的细胞粘附的分子基础
- 批准号:
1412472 - 财政年份:2014
- 资助金额:
$ 67.5万 - 项目类别:
Continuing Grant
The Molecular Basis of Cadherin-Mediated Cell Adhesion
钙粘蛋白介导的细胞粘附的分子基础
- 批准号:
0918535 - 财政年份:2009
- 资助金额:
$ 67.5万 - 项目类别:
Continuing Grant
Theoretical Studies of Membrane Proteins
膜蛋白的理论研究
- 批准号:
0416708 - 财政年份:2004
- 资助金额:
$ 67.5万 - 项目类别:
Continuing Grant
Rapid Computational Analysis of Biomolecular Properties
生物分子特性的快速计算分析
- 批准号:
9904841 - 财政年份:1999
- 资助金额:
$ 67.5万 - 项目类别:
Continuing Grant
Rapid Computational Analysis of Biomolecular Properties
生物分子特性的快速计算分析
- 批准号:
9601463 - 财政年份:1996
- 资助金额:
$ 67.5万 - 项目类别:
Continuing Grant
Theoretical Studies of Membrane Proteins
膜蛋白的理论研究
- 批准号:
9304127 - 财政年份:1993
- 资助金额:
$ 67.5万 - 项目类别:
Continuing Grant
Rapid Computational Analysis of Biomolecular Properties
生物分子特性的快速计算分析
- 批准号:
9207256 - 财政年份:1992
- 资助金额:
$ 67.5万 - 项目类别:
Continuing Grant
Modeling Facility for Molecular Biology
分子生物学建模设施
- 批准号:
8720229 - 财政年份:1989
- 资助金额:
$ 67.5万 - 项目类别:
Continuing Grant
相似海外基金
Theoretical studies on membrane deformation patterns of grana thylakoid morphogenic membrane proteins
基粒类囊体形态发生膜蛋白膜变形模式的理论研究
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318727-2005 - 财政年份:2007
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Theoretical Studies of Membrane Protein Folding
膜蛋白折叠的理论研究
- 批准号:
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- 资助金额:
$ 67.5万 - 项目类别:
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Theoretical Studies of Membrane Protein Folding
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- 批准号:
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Theoretical Studies on the Dynamics of Ion Permeation Across Membrane Channels
离子透过膜通道动力学的理论研究
- 批准号:
nhmrc : 316907 - 财政年份:2005
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Theoretical Studies of Membrane Proteins
膜蛋白的理论研究
- 批准号:
0416708 - 财政年份:2004
- 资助金额:
$ 67.5万 - 项目类别:
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膜与小分子、肽、膜蛋白相互作用的理论研究
- 批准号:
238357-2001 - 财政年份:2001
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Theoretical studies of the interactions between membranes and small molecules, peptides and membrane proteins
膜与小分子、肽、膜蛋白相互作用的理论研究
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流体-溶质-膜系统的实验和理论研究
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- 资助金额:
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