The physiological importance of GLP-1R and GIPR dimerisation

GLP-1R 和 GIPR 二聚化的生理重要性

• 批准号: DP230102777
• 负责人: Prof Denise Wootten
• 金额: $ 41.12万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102777
• 关键词: physiological; importance; GLP; 1R; GIPR

Cell surface receptors are vital for relaying information from hormones to the cell to influence cell function, and ultimately physiological responses. Receptors can form oligomers with other receptors, but whether this can influence cellular and physiological responses is not yet defined. This biology-based project aims to bridge this knowledge gap by studying the dimerisation between two related receptors involved in whole body metabolic homeostasis. Our team will deliver new knowledge into the disciplines of pharmacology, cellular biology, metabolism and physiology, and provide interdisciplinary research training to students and junior scientists, and strengthen research collaboration within and outside of Australia.

细胞表面受体对于将信息从激素传递到细胞以影响细胞功能并最终影响生理反应至关重要。受体可以与其他受体形成寡聚体，但这是否会影响细胞和生理反应尚未确定。这个基于生物学的项目旨在通过研究参与全身代谢稳态的两个相关受体之间的二聚化来弥合这一知识差距。我们的团队将为药理学，细胞生物学，代谢和生理学学科提供新知识，并为学生和初级科学家提供跨学科的研究培训，并加强澳大利亚内外的研究合作。