Conformational Transitions in Polypeptides
Conformational Transitions in Polypeptides
批准号:
8722238
负责人:
Wayne Mattice
金额:
$20.0万
依托单位:
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
1988
资助国家:
美国
项目状态:
已结题
起止时间:
1988-07-01 至 1991-12-31
中文摘要
理论和实验相结合的方法将被用来理解多肽链中如何形成β-折叠。这项研究的理论部分将继续马蒂斯博士最近提出的贝塔薄片到线圈转变理论的演变。还将开发荧光方法来研究板材到盘管的转变。尽管知道α螺旋和β折叠的结构已经有一段时间了,但目前对螺旋形成的了解远远超过了对β折叠形成的了解。马蒂斯博士的理论工作代表着在理解蛋白质变性和折叠的基本物理化学方面取得了重大进展。
英文摘要
A combination of theoretical and experimental methods will be used to understand how beta sheets are formed in polypeptide chains. The theoretical portion of the research will continue the evolution of Dr. Mattice's recently introduced theory of the beta sheet to coil transition. Fluorescence methods will also be developed for study of the sheet to coil transition. Although the structures of alpha helix and beta sheets have been known for some time, the current understanding of helix formation far surpasses the knowledge of the formation of beta sheets. The theoretical work done by Dr. Mattice represents a significant advance in understanding the basic physical chemistry of protein denaturation and folding.***
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Configuration and Dynamics in Large Polymer Systems
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批准号:0098321
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项目类别:Continuing Grant
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资助金额:$46.0万
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财政年份:2001
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负责人:Wayne Mattice
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依托单位:
Configuration and Dynamics in Large Polymeric Systems
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批准号:9523278
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项目类别:Continuing Grant
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资助金额:$45.0万
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财政年份:1996
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负责人:Wayne Mattice
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依托单位:
U.S.-Switzerland-Germany Cooperation in the Semi-Atomistic Simulation of Macromolecules
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批准号:9421585
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项目类别:Standard Grant
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资助金额:$2.46万
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财政年份:1995
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负责人:Wayne Mattice
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依托单位:
U.S.-Turkey Cooperative Research on Dynamics in Polymeric Systems
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批准号:9312285
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项目类别:Continuing Grant
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资助金额:$3.06万
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财政年份:1993
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负责人:Wayne Mattice
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依托单位:
Dynamics of Polyesters and Constrained Polymeric Hydrocarbons
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批准号:9220369
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项目类别:Continuing Grant
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资助金额:$24.12万
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财政年份:1993
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负责人:Wayne Mattice
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依托单位:
U.S.-Australia Cooperative Research: Macromolecular Modeling of Polymeric Stabilization of Colloidal Dispersions
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批准号:9014836
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项目类别:Standard Grant
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资助金额:$0.76万
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财政年份:1991
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负责人:Wayne Mattice
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依托单位:
Rapid Atom-Based Analysis of the Intramolecular Dynamics of Polymers
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批准号:8915025
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项目类别:Continuing Grant
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资助金额:$19.8万
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财政年份:1990
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负责人:Wayne Mattice
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依托单位:
US-New Zealand Cooperative Research: Proanthocyanidin Polymers and their Complexes
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批准号:8619526
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项目类别:Standard Grant
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资助金额:$0.3万
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财政年份:1987
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负责人:Wayne Mattice
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依托单位:
Electro-Optical Properties of Vinyl Polymers
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批准号:8696071
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项目类别:Continuing Grant
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资助金额:$16.41万
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财政年份:1986
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负责人:Wayne Mattice
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依托单位:
Conformational Transitions in Polypeptides
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批准号:8696070
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项目类别:Standard Grant
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资助金额:$12.5万
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财政年份:1986
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负责人:Wayne Mattice
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依托单位:
Conformational Transitions in Polypeptides
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批准号:8500338
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项目类别:Standard Grant
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资助金额:$5.0万
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财政年份:1985
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负责人:Wayne Mattice
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依托单位:
The Kerr Effect in Monosubstituted Vinyl Polymers; U.S.-Spain Program
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批准号:8501408
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项目类别:Standard Grant
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资助金额:$0.0万
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财政年份:1985
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负责人:Wayne Mattice
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依托单位:
Electro-Optical Properties of Vinyl Polymers (Materials Research)
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批准号:8315547
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项目类别:Continuing Grant
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资助金额:$8.6万
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财政年份:1984
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负责人:Wayne Mattice
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依托单位:
Lipid-Induced Changes in Peptide Hormones
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批准号:8118197
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项目类别:Continuing Grant
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资助金额:$13.5万
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财政年份:1982
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负责人:Wayne Mattice
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依托单位:
Conformational Changes Induced in Proteins By Lipids
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批准号:7822916
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项目类别:Continuing Grant
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资助金额:$10.5万
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财政年份:1979
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负责人:Wayne Mattice
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依托单位:
Configuration-Dependent Properties of Branched Molecules Of Biological Interest
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批准号:7623235
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项目类别:Standard Grant
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资助金额:$4.5万
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财政年份:1977
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负责人:Wayne Mattice
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依托单位:
Interactions Between Salts and Polypeptides
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批准号:7202416
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项目类别:Standard Grant
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资助金额:$6.8万
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财政年份:1972
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负责人:Wayne Mattice
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依托单位:
海外基金