Photoinduced Palladium Catalysis for Next Generation C-H Bond Activation

光诱导钯催化下一代 C-H 键活化

• 批准号: DP230102752
• 负责人: A/Prof Anastasios Polyzos
• 金额: $ 40.79万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102752
• 关键词: Photoinduced; Palladium; Catalysis; Next; Generation

This project aims to discover new methods for the conversion of carbon-hydrogen bonds in organic molecules as a general strategy in chemical synthesis. A key conceptual advance in this project is the unification of transition metal catalysis and visible light as a powerful tool to activate these traditionally unreactive, yet abundant chemical bonds in alkanes. With application in fields that range from fine chemical production to drug discovery, the overarching aim of this research is to establish new carbon-hydrogen bond activation reactions and to demonstrate that this strategy can be translated to the invention of new pharmaceuticals, agrochemicals and advanced synthetic materials that will have societal impact.

该项目旨在发现有机分子中碳 - 氢键转化为化学合成的一般策略的新方法。该项目中的一个关键概念进步是统一过渡金属催化和可见光，作为激活这些传统上无反应性但丰富的化学键的强大工具。随着从精细的化学生产到药物发现范围内的领域，这项研究的总体目的是建立新的碳氧键激活反应，并证明该策略可以转化为新的药物，农业化学物质和先进的合成材料的发明，以具有社会影响。