Cooperative Chiral Anion Phase-Transfer and Palladium-Catalysis to the Oxyarylation of Homoallylic Alcohols and to the Synthesis of Indolines

过渡金属催化的交叉偶联反应和手性阴离子相转移(CAPT)催化已经是合成有机化学中最重要的转化之一。然而，这两种方法的组合很少被描述。因此，在这个项目中，提出了一种将手性阴离子相转移(CAPT)和钯催化相结合的新策略，以选择性地形成单一的光学纯产品。一旦找到合适的催化体系，就可以制备手性四氢呋喃衍生物。此外，该催化体系还可用于分子内协同的CAPT和Pd催化。因此，各种具有有趣药用性质的官能化吲哚类化合物(如乙酰胆碱酯酶抑制剂或抗癌药物)将很容易高效地获得。

Transition metal-catalyzed cross-coupling reactions and Chiral Anion Phase-Transfer (CAPT) catalysis are already among the most important transformations in synthetic organic chemistry. However, only few combinations of these two methods have been described. Consequently, a novel strategy for the combination of Chiral Anion Phase-Transfer (CAPT) and palladium-catalysis is proposed in this project for the selective formation of a single, optically pure product. Once a suitable catalytic system is found, chiral tetrahydrofuran derivatives will be prepared. Furthermore, this catalytic system can be adapted for an intramolecular cooperative CAPT and Pd-catalysis. Thus, various functionalized indolines with interesting medicinal properties (e.g. acetylcholinesterase inhibitors or anticancer agents) will be easily accessible with high efficiency.