Characterising a novel stress-sensing signalling factor

表征新型压力感应信号因子

• 批准号: DP230102652
• 负责人: A/Prof Benjamin Parker
• 金额: $ 51.25万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-17 至 2026-01-16
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102652
• 关键词: Characterising; novel; stress; sensing; signalling

Aim: To understand how phosphorylation regulates signalling pathways to allow metabolic adaptations in response to energetic stress. Significance: A fundamental understanding of the activation of signalling pathways via phosphorylation is vital for our knowledge of homeostasis and the mechanisms controlling cell survival. Expected outcomes: To generate new systems biology and physiology data to understand how the stress response is regulated and characterise new stress-sensing pathways. Benefits: A greater understanding of the molecular mechanisms controlling metabolism in response to stress has extremely broad applications to improve metabolic efficiency in fields ranging from exercise- and life-sciences to agriculture.

目的：了解磷酸化如何调节信号通路，使代谢适应能量应激。重要性：对通过磷酸化激活信号通路的基本理解对于我们了解稳态和控制细胞存活的机制至关重要。预期成果：产生新的系统生物学和生理学数据，以了解压力反应是如何调节的，并探索新的压力感应途径。优点：更好地了解控制代谢的分子机制，以应对压力，具有非常广泛的应用，以提高代谢效率的领域，从运动和生命科学的农业。