NanoRAM: Emerging Nanotools for Soft Matter Characterisation and Manipulation

先进的纳米工具，包括原子力显微镜，光学显微镜和相关显微镜，使技术的发现和知识的产生在纳米科学和技术。许多研究与开发工作都致力于改善这类软物质技术的性能。然而，这些前沿技术面临的最大挑战是实现高时空分辨率、无创、多尺度和多维成像和操作。因此，我们建议NanoRAM，一个10 ESR玛丽Sklodowska居里行动博士网络学术和工业合作伙伴之间的密切合作，围绕创新的纳米工具及其工业应用的主题。NanoRAM将在软物质研究中开发和应用新开发的操纵和表征纳米工具方面培养新一代ESR。ESR将与仪器和软物质表征的概念和技能交叉授粉，特别是在快速纳米力学光谱学，纳米机器人，相关的超分辨率纳米显微镜，纳米生物力学和机械转导。这些技术首次用于揭示单细胞生物力学和纳米医学的快速，高分辨率，多层次和3D信息。在新的科学和补充技能方面的优秀培训，加上国际和跨部门的工作经验，将在ESRs中灌输创新，创造性和创业精神，最大限度地提高基于科学发现的经济效益。这些专业化、训练有素的ESRs将大大提高职业前景和获得私营和公共部门责任职位的资格。NanoRAM的最终目标是巩固欧洲在创新纳米工具技术及其在生物力学，机械生物学和纳米医学等软物质领域的新兴应用方面的世界领先地位。

Advanced nanotools including atomic force microscopy, optical microscopy and correlative microscopy are enabling techniques for discoveries and knowledge generation in nanoscale science and technology. Many R&D efforts have been directed towards the performance improvement of such kinds of techniques for soft matter. However, the greatest challenge faced by these leading edge techniques is the realization of high spatiotemporal resolution, non-invasive, multi-scale and multi-dimensional imaging and manipulation. We therefore propose NanoRAM, a 10 ESR Marie Sklodowska Curie Action Doctoral Network by close collaboration between academic and industrial partners around the theme of innovative nanotools and their industrial applications. NanoRAM will train a new generation of ESRs in the development and application of newly developed manipulation and characterisation nanotools in soft matter research. ESRs will be cross-pollinated with concepts and skills in instrumentation and soft matter characterisation, in particular in fast nanomechanical spectroscopy, nano-robotics, correlative super-resolution nanoscopy, nano biomechanics and mechanotransduction. These skills are applied to reveal for the first time the fast, high resolution, multi-level and 3D information for single cell biomechanics and nanomedicine. Excellent training in new scientific and complementary skills, combined with international and intersectoral work experience, will instil an innovative, creative and entrepreneurial mind-set in ESRs, maximising economic benefits based on scientific discoveries. These specialised, highly trained ESRs will have greatly enhanced career prospects and qualifications for access to responsibility job positions in the private and public sectors. The ultimate goal of NanoRAM is to consolidate Europe as the world leader in innovative nanotool techniques and their emerging applications in soft matter fields such as biomechanics, mechanobiology, and nanomedicines.