U.S.-Mexico Cooperative Research: Geometry and Electron Transfer Studies of Selected Sulfur Substituted Heterocycles

该奖项将支持亚利桑那大学(UA)的理查德·格拉斯教授和墨西哥墨西哥城国家理工学院(IPN)的尤西比奥·华里斯蒂教授之间的合作。研究人员打算研究影响生物系统中电子转移反应路径的几何因素。利用构象结构分析和电化学方法合成，研究人员打算探索具有相当大生物化学兴趣的含硫杂环的微妙立体电子性质。该方法很好地平衡了综合开发和机理研究。此外，该项目证明了互补技能的良好匹配，UA提供了强大的分析能力，而IPN则在合成方面贡献了力量。此外，该项目延续了两位研究人员以前的成功合作，从而开发了一种适用于拟议工作的实用电合成方法。

This award will support collaborative work between Prof. Richard Glass of the University of Arizona (UA) and Prof. Eusebio Juaristi of the Instituto Politecnico Nacional (IPN) in Mexico City, Mexico. The researchers intend to study geometric factors that affect the reaction pathway of electron transfer in biological systems. Using conformational-structural analyses and synthesis by electrochemical methods, the researchers intend to probe subtle stereoelectronic properties of sulfur-containing heterocycles that are of considerable biochemical interest. The approach has a good balance of synthetic development and mechanistic studies. Furthermore, the project evidences a good match of complementary skills with the UA providing a strong analytical capability while the IPN contributes its strength in synthesis. Additionally the project continues a previous successful collaboration between the two investigators, which led to the development of a practical electrosynthesis method applicable to the proposed work.