U.S.-Mexico Cooperative Research: Glycosylation with C(1) Metalated Glycosides

9602925玻璃美国计划奖将资助亚利桑那大学图森分校的理查德·格拉斯博士和墨西哥伊利诺伊州尤西比奥·华里斯蒂博士之间的合作研究项目。本研究旨在通过在温和和中性的氧化条件下产生糖氧碳正离子来开发合成糖苷的新方法。该反应用于糖苷、核苷和C-糖苷的形成，以确定糖苷和相关化合物的构象行为。模型化合物将用于系统地研究该方法的可行性，以及对邻位取代基的耐受性。这是目前相当有兴趣的研究领域，如果研究成功，这项研究可能会产生糖和核苷化学的有用方法，潜在地应用于开发新的治疗药物。对于这个项目，铁络合物的合成及其氧化还原化学将在亚利桑那州进行，它们的构象分析和选定的FP糖前体的合成将在墨西哥进行。***

9602925 Glass This Americas Program award will fund a collaborative research project between Drs. Richard Glass, University of Arizona, Tucson, and Eusebio Juaristi, I.P.N., Mexico. The research aims to develop new methods for synthesis of glycosides by generating sugar oxocarbenium ions under mild and neutral oxidizing conditions. The use of this reaction for the formation of glycosides, nucleosides, and C- glycosides will be investigated to ascertain the conformational behavior of the glycosides and related compounds. Model compounds will be used in a systematic study of the feasibility of the method, and on the tolerance to neighboring substituents. This is an area of considerable current research interest and, if successful, the study may generate useful methods for saccharide and nucleoside chemistry of potential application to the development of new therapeutic agents. For this project, the synthesis of the iron complexes and their redox chemistry will be done in Arizona, and their conformational analysis and synthesis of selected precursors of the Fp sugars will be carried out in Mexico. ***