US-Polish Research on Chemistry of Phosphorus Selenium Compounds

这个美国-波兰联合合作研究 磷硒化合物化学 理查德·S。大学的玻璃 亚利桑那州图森市和扬·米哈尔斯基博士， 亚历山大·斯考伦斯卡 的分子和大分子研究 波兰研究学院。 研究人员 将发展硒磷酸盐的化学性质， 设计化学选择性合成 有机硒化合物作为模型 硒部分的选择性引入 转化为蛋白质和RNA， 与真实化合物的比较，P-Se 酶促产生的化合物。 拟议 国际合作是相互的 因为波兰人的广泛 经验和专业知识， 有机磷硒合成 化合物的补充机制 和~（77）NMR波谱经验 美国集团。 这项合作将 加强和扩大研究工作， 合作团体的基础设施。 提出的化学选择性方法， 将硒引入生物分子，如果 成功，将允许引入 有价值的77Se NMR光谱标记物。 这 标记将允许使用NMR进行结构研究 这些大分子的光谱学（一个项目 美国小组和TC博士 Stadtman of NIH collaboration）。 此等方法 也将有助于综合 含硒半合成酶 活跃的网站，具有潜在的新的和有用的 催化活性以及合成 多波长生物分子衍生物 异常衍射结构研究 这项拟议中的化学研究满足了 推进科学的计划目标， 使美国和欧洲的领先专家能够 波兰将联合收割机互补的人才和 集中研究资源， 共同利益和能力。

This U.S.-Poland Joint Cooperative Research on Chemistry of Phosphorous Selenium Compounds is between Dr. Richard S. Glass of the University of Arizona Tucson and Drs. Jan Michalski, and Aleksandra Skowronska of the Centre of Molecular and Macromolecular Studies of the Polish Academy of Studies. The researchers will develop the chemistry of selenophosphates, devise chemoselective synthesis of organoselenium compounds as models for selective introduction of selenium moieties into proteins and RNA's, and identification, by comparison with authentic compounds, of P-Se compounds produced enzymatically. The proposed international collaboration is mutually beneficial because the Polish group's extensive experience and expertise in the difficult synthesis of organophosphorus-selenium compounds is complemented by the mechanistic and 77 NMR spectroscopic experience of the American group. This collaboration will strengthen and broaden the research efforts and infrastructure of the collaborating groups. The proposed chemoselective methods for introducing selenium into biomolecules, if successful, would permit introduction of the valuable 77Se NMR spectroscopic label. This label would allow structure studies using NMR spectroscopy of these macromolecules (a project in which the American group and Dr. T.C. Stadtman of NIH collaborate). Such methodology would also facilitate synthesis of semisynthetic enzymes with selenium at their active site with potentially new and useful catalytic activities as well as synthesis of derivatives of biomolecules for multiwavelength anomalous diffraction structural studies. This proposed research in chemistry fulfills the program objectives of advancing science by enabling leading experts in the U.S. and the Poland to combine complementary talents and pool research resources in areas of strong mutual interest and competence.