Photoacoustic cellular manipulation: building from the bottom up

光声细胞操纵：自下而上构建

• 批准号: DP230102550
• 负责人: Dr David Collins
• 金额: $ 30.2万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102550
• 关键词: Photoacoustic; cellular; manipulation; building; bottom

In this project we propose an approach for creating complex 3D prints. Whereas current approaches are limited to defining the external geometry, this technology will permit the organization of the internal structure as well, with the potential to do so at the scale of individual cells. Achieving this has important applications in bioprinting human tissues and additive manufacturing. This is based on the manipulation of particles and cells using holographic acoustic fields controlled by patterned light. This is compared to current acoustic patterning approaches are mostly limited to static simple geometric arrangements and lack the flexibility to produce arbitrary, rapidly changing fields that enable the fabrication of complex structures.

在这个项目中，我们提出了一种创建复杂3D打印的方法。虽然目前的方法仅限于定义外部几何形状，但这项技术也将允许组织内部结构，并有可能在单个细胞的规模上这样做。实现这一目标在生物打印人体组织和增材制造方面具有重要应用。这是基于使用由图案化光控制的全息声场来操纵粒子和细胞。这与当前的声学图案化方法相比，该方法大多限于静态的简单几何布置，并且缺乏产生任意的、快速变化的场的灵活性，该场使得能够制造复杂结构。