Nuclear Spin Relaxation in Biomolecules as a Probe for Solution Dynamics and Structure

生物分子中的核自旋弛豫作为溶液动力学和结构的探针

• 批准号: 8803611
• 负责人: Gerd La Mar
• 金额: $ 24.2万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1992-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8803611&HistoricalAwards=false
• 关键词: Nuclear; Spin; Relaxation; Biomolecules; Probe

This project has two components. The first involves the structural and functional properties of the 1:1 complex between cytochrome b5 and other redox partner proteins and the second, the characterization by NMR of dynamic properties of selected heme proteins. The research will continue to explore and elucidate, using diverse NMR methods, a wide range of dynamic properties of heme proteins which are likely the key to understanding both their biophysical properties as well as their functions. Biological electron transport is currently one of the most intensely studied of biological processes in which heme proteins play a major role. Knowledge of the structures and dynamic motions of these important molecules is essential in understanding the processes so essential to life.

该项目有两个组成部分。 第一个涉及 1：1复合物的结构和功能性质 细胞色素b5和其他氧化还原伴侣蛋白之间的相互作用， 第二，动力学性质的NMR表征 选择血红素蛋白质。 研究将继续 探索和阐明，使用不同的核磁共振方法，广泛的 血红素蛋白质的一系列动态特性， 理解它们的生物物理特性的关键， 以及它们的功能。 生物电子传递是目前最重要的 对生物过程的深入研究， 蛋白质起主要作用。 了解结构和 这些重要分子的动态运动是必不可少的， 了解生命的基本过程