Acquisition of a High Field NMR Spectrometer

这项赠款提案要求为分子生物学中用于高分辨率光谱分析的垂直口径、高场强核磁共振光谱仪提供部分资金。该仪器将包括经过验证的最高磁场磁铁(11.75T)，足够容纳10 mm管的均匀体积，以及一个控制台，具有先进技术所需的所有功能，如多维和多量子实验、异核质子探测、自旋锁定以及产生复杂脉冲相位脉冲序列的能力。光谱仪将由六名调查人员(主要用户)和几个次要用户组成的核心小组使用。研究人员的个人项目涵盖了分子生物学的广泛基础研究。每个研究人员都有一个用较小能力的光谱仪进行核磁共振研究的既定计划，该提案记录了通过拟议仪器的新功能将获得的额外知识。拟议的仪器将由UCD核磁共振设施赞助。该设施拥有十多年的可靠记录，使研究人员能够实施最先进的核磁共振技术，以及光谱仪的维护和改进。

This grant proposal requests partial funding for a vertical bore, high field NMR spectrometer for high resolution spectroscopy in molecular biology. The instrument will consist of the highest proven field magnet (11.75T), sufficient homogeneous volume for 10mm tubes, and a console with all features necessary for advanced techniques such as multidimensional and multiple quantum experiments, proton detection of heteronuclei, spin locking, and capability of generating pulse sequences of complex pulse phase. The spectrometer will be utilized by a core group of six investigators (Primary users) as well as several minor users. The individual projects of the investigators cover a wide range of fundamental research in molecular biology. Every investigator has an established program of NMR research with spectrometers of lesser capability and the proposal documents the additional knowledge to be gained by the new capabilities of the proposed instrument. The proposed instrument will come under the auspices of the UCD NMR Facility. The Facility has a proven record over ten years in enabling investigators to implement state of the art NMR techniques, and in spectrometer maintenance and modification.