Acquisition of a High Field NMR Spectrometer

这项拨款申请要求为垂直钻孔提供部分资金， 高场核磁共振波谱仪 分子生物学 该仪器将包括最高的 经过验证的磁场磁铁（11.75T），足够均匀的体积， 10毫米管，以及一个控制台， 先进的技术，如多维和多量子 实验，异质核的质子探测，自旋锁定， 产生复脉冲相位的脉冲序列的能力。 光谱仪将由六人核心小组使用 调查人员（主要用户）以及一些次要用户。 调查人员的个人项目涉及范围广泛 分子生物学的基础研究。 每个调查员 有一个既定的计划，核磁共振研究与光谱仪 能力较低，建议书记录了额外的 通过拟议的新能力获得的知识 仪器 拟议的文书将由UCD主持 NMR设备。 该设施在过去十年中， 使研究人员能够实施最先进的核磁共振技术 技术，以及光谱仪的维护和修改。

This grant proposal requests partial funding for a vertical bore, high field NMR spectrometer for high resolution spectroscopy in molecular biology. The instrument will consist of the highest proven field magnet (11.75T), sufficient homogeneous volume for 10mm tubes, and a console with all features necessary for advanced techniques such as multidimensional and multiple quantum experiments, proton detection of heteronuclei, spin locking, and capability of generating pulse sequences of complex pulse phase. The spectrometer will be utilized by a core group of six investigators (Primary users) as well as several minor users. The individual projects of the investigators cover a wide range of fundamental research in molecular biology. Every investigator has an established program of NMR research with spectrometers of lesser capability and the proposal documents the additional knowledge to be gained by the new capabilities of the proposed instrument. The proposed instrument will come under the auspices of the UCD NMR Facility. The Facility has a proven record over ten years in enabling investigators to implement state of the art NMR techniques, and in spectrometer maintenance and modification.