Engineering Research Equipment Grant: Automatic Light Scattering Goniometer and Photon Correlator for Colloidal Polymer Biochemical and Pharmaceutical Research

本工程设备项目提供了一种准弹性轻 散射（QELS）设备需要五个正在进行的研究 四名教师在以下领域进行的项目 胶体、聚合物、生物化学和药物研究。 的 首先（得到DOE的支持），涉及表面活性剂的减阻 用于区域供热和区域供冷系统。 第二个（由NSF通过工程研究支持） 俄亥俄州州立和私营工业中心）处理 非均匀交联微结构的形成 聚合。 第三个（由俄亥俄州支持 托马斯爱迪生计划和私营企业）处理 反应性加工中的扩散控制聚合。 的 第四（目前由俄亥俄州内部支持 国家）处理生物聚合物和生物粒子的形成 在发酵中。 第五类（由私营企业支持） 研究各种药物输送系统 这些行为 系统强烈地依赖于分子量、颗粒尺寸和 颗粒形状在亚微米范围内。 QELS测量将 准确有效地提供这些信息， 对潜在现象的更基本的分析。 QELS装置允许测量胶束尺寸， 形状，因此，胶束尺寸标准的发展 以及有效减阻沿着标准所需的形状 对于表面活性剂化学结构和溶剂环境， 提供这些胶束结构。 这将允许 选择新的、有用的减阻表面活性剂添加剂， 低温（40-55华氏度）区域冷却 及高温（摄氏80度及以上）地区 加热系统 这些系统节约能源， 在小型低效供暖或制冷机组上的投资， 在炎热的夏天减少高峰电力负荷。 微结构材料、先进聚合物、复合材料等， 正在重塑我们的社会， 生活水平。 了解微结构是如何形成的 以及学习如何控制所涉及的过程 将对材料的发展做出重要贡献 设计和制造。 不饱和聚酯树脂具有 在汽车、住房、船舶和 电气/电子行业，是最广泛使用的 热固性塑料。 这项研究中开发的技术也可以 适用于其他微结构材料。

This engineering equipment project provides a quasi-elastic light scattering (QELS) device needed for five on-going research projects conducted by four faculty members in the areas of colloidal, polymer, biochemical and pharmaceutical research. The first (supported by DOE), deals with drag reduction in surfactant systems for use in district heating and district cooling systems. The second (supported by NSF through the Engineering Research Center at Ohio State and private industries) deals with microstructure formation in inhomogeneous crosslinking polymerizations. The third (supported by the State of Ohio Thomas Edison Program and private industries) deals with diffusion-controlled polymerizations in reactive processing. The fourth (which is currently being supported internally by Ohio State) deals with the formation of bioploymers and bioparticles in fermentation. The fifth (supported by private industries) deals with various drug delivery systems. The behavior of these systems strongly depends on molecular weight, particle size and particle shape in the submicron range. QELS measurements would provide this information accurately and efficiently, leading to more fundamental analyses of the underlying phenomena. The QELS apparatus allows the measurement of micellar size and shape and, therefore, the development of criteria of micelle size and shape needed for effective drag reduction along with criteria for surfactant chemical structures and solvent environments which provide these micellar structures. This will permit the selection of new, useful, drag reducing surfactant additives for both low temperature (40-55 degrees Fahrenheit) district cooling and high temperature (80 degrees Celsius and above) district heating systems. These systems conserve energy, reduce investment in small inefficient heating or cooling units, reduce pollution and reduce peak electricity loads on hot summer days. Microstructural materials, advanced polymers, composites, etc., are reshaping our society and are contributing to an improved standard of living. Understanding how microstructures are formed in materials and learning how to control the processes involved in their formation will make important contributions to materials design and manufacturing. Unsaturated polyester resins have shown remarkable growth in the automotive, housing, marine and electric/electronics industries and are the most widely used thermosets. The technology developed in this study could also be applied to other microstructures materials.