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Equipment for studying locomotion to be used in animal biomechanics animal welfare developmental biology and engineering research

用于动物生物力学、动物福利、发育生物学和工程研究的运动研究设备

基本信息

批准号：
BB/E013244/1
负责人：
Alan Wilson
金额：
$ 30.8万
依托单位：
Royal Veterinary College
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2007
资助国家：
英国
起止时间：
2007 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FE013244%2F1
关键词：
Equipment studying locomotion used animal

项目摘要

To undertake novel fundamental and applied research in animal (including human) biomechanics we wish to purchase a range of gait analysis equipment (treadmills, force plates, motion analysis cameras, high speed video cameras, fluoroscopy system). This will complement our existing locomotion research facilities and will be housed in a new radio-screened 46 x 16 metre gait lab being built (SRIF funding) to provide a physically ideal and adaptable research environment for biomechanics. It will enable a wide range of users from many related disciplines to undertake studies in basic animal mechanics, animal welfare and behaviour, developmental biology and muscle physiology; including, for the first time, using genetically modified mice to investigate how genes that affect the development of muscle/tendons etc influence adult muscle physiology. This work will pioneer non-invasive methods for this type of research. We will investigate aspects of musculoskeletal structure and design for locomotion, and their impact on injury, dysfunction, disease and ageing. The research methods concentrate on measuring forces and stresses in bones, tendons, muscles and joints because mechanical load is critical in the formation, maintenance and disruption of these tissues. Determination of mechanical load is derived from measurement of movement (Motion Analysis and high speed video), external forces (force plates) during exercise (treadmills and runways) and existing equipment for muscle fibre mechanics (ultrasound and sonomicrometry), activity (EMG), imaging (radiography, CT and two MRI systems) and computer simulation. Specifically, we will be able to record full-body video, Motion Analysis on terrestrial animals from mouse to horse on treadmills, and freely running or flying mammals and birds; measure individual limb ground reaction forces for animals of similar size range; and measure skeletal movements using video fluoroscopy of vertebrates up to the size of an elephant. We will thus be able to undertake a diverse range of research applications which fall within the BBSRC priority areas of ageing, maths biology interface, integrative mammalian biology and whole animal physiology. In addition, this equipment will provide us with the unique capability to assess and quantify the mechanical consequences genetic modifications in mice, completing the pathway from most proximal to most derived function (genes to locomotory ability). The lab is the research base for 6 HEFCE funded staff and an area of prime research activity for a further 7 HEFCE staff. External users include academics from UCL orthopaedics, computing and medical physics, Cambridge computing, engineering and zoology, York psychology, Bath sports science, Bristol earth sciences, and others from universities within the UK, Europe and the USA. Five post docs, 2 technicians and 13 PhD students are based in the lab. We hold BBSRC, DEFRA, Royal Society and EPSRC funding. The PI and a co-applicant hold BBSRC RD Fellowships; the PI also holds a Royal Society Wolfson Research Merit award. The core group has published 88 papers including 6 in Nature (one a review). Technical support is provided by a full time HEFCE funded lab manager (MSc Zoology, Wageningen), an electronics design engineer (joint with Welfare group) and a zoology graduate technician. This proposal will give excellent value for money as equipment turnover, running and maintenance costs are low. This enables us to maximise utilisation of all our equipment since we can undertake external and institutionally funded internal, pilot and PhD projects and allow visitors and collaborators to do the same. The lab is a focus for visiting researchers because of our reputation for excellent science, our range of equipment and our policy of welcoming visiting scientists. Success in this application will enable us to accommodate and accomplish a greater breadth and depth of research and to remain at the forefront of world bioscience

为了在动物(包括人类)生物力学方面进行新的基础和应用研究，我们希望购买一系列步态分析设备(跑步机、测力板、运动分析相机、高速摄像机、透视系统)。这将补充我们现有的运动研究设施，并将被安置在一个新的无线电筛选步态实验室(SRIF资助)中，为生物力学提供一个理想的、适应性强的研究环境。它将使来自许多相关学科的广泛用户能够进行基础动物力学、动物福利和行为、发育生物学和肌肉生理学的研究；包括首次使用转基因小鼠来研究影响肌肉/肌腱等发育的基因如何影响成人肌肉生理学。这项工作将开创这类研究的非侵入性方法。我们将研究肌肉骨骼结构和运动设计的各个方面，以及它们对损伤、功能障碍、疾病和衰老的影响。研究方法集中在测量骨骼、肌腱、肌肉和关节的力和应力，因为机械载荷在这些组织的形成、维持和破坏中起着关键作用。通过测量运动(运动分析和高速录像)、运动中的外力(力板)(跑步机和跑道)和现有的肌肉纤维力学设备(超声波和声学显微镜)、活动度(EMG)、成像(X线片、CT和两个MRI系统)和计算机模拟来确定机械载荷。具体地说，我们将能够记录全身视频，在跑步机上从老鼠到马的陆地动物的运动分析，以及自由奔跑或飞行的哺乳动物和鸟类；测量类似大小范围的动物的单个肢体地面反作用力；以及使用视频透视测量大象大小的脊椎动物的骨骼运动。因此，我们将能够承担BBSRC优先领域的各种研究应用，如老龄化、数学生物学接口、综合哺乳动物生物学和整体动物生理学。此外，该设备将为我们提供独特的能力来评估和量化小鼠基因修改的机械后果，完成从最近端到最衍生功能(基因到运动能力)的途径。该实验室是6名HEFCE资助的工作人员的研究基地，也是另外7名HEFCE工作人员的主要研究活动区域。外部用户包括来自伦敦大学学院整形外科、计算机和医学物理、剑桥计算机、工程和动物学、约克心理学、巴斯体育科学、布里斯托尔地球科学的学者，以及来自英国、欧洲和美国大学的其他学者。实验室里有5名博士后、2名技术人员和13名博士生。我们持有BBSRC、DEFRA、皇家学会和EPSRC的资金。该协会和一名共同申请者拥有BBSRC研发奖学金；该协会还拥有皇家学会沃尔夫森研究功勋奖。核心小组发表了88篇论文，其中6篇发表在《自然》杂志上(一篇是综述)。技术支持由HEFCE资助的一名全职实验室经理(瓦格宁根动物学硕士)、一名电子设计工程师(与福利团体联合)和一名动物学研究生技术员提供。由于设备周转、运行和维护成本低，这项建议将带来极高的性价比。这使我们能够最大限度地利用我们所有的设备，因为我们可以承担外部和机构资助的内部、试点和博士项目，并允许参观者和合作者这样做。该实验室是来访研究人员的焦点，因为我们以卓越的科学而闻名，我们的设备范围和我们欢迎来访科学家的政策。这一应用的成功将使我们能够适应和实现更大的研究广度和深度，并保持在世界生物科学的前沿