Kinetic and Equilibrium Factors in the Effective Recovery ofBiochemicals by Precipitation

沉淀有效回收生化物质的动力学和平衡因素

• 批准号: 8810214
• 负责人: Donald Kirwan
• 金额: $ 13.2万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-06-01 至 1991-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8810214&HistoricalAwards=false
• 关键词: Kinetic; Equilibrium; Factors; Effective; Recovery

This is a fundamental study of crystallization of biological compounds by the addition of organic non-solvents. The reserch encompasses a study of solubilities of eight model amino acids and two model antibiotics under different environmental conditions, and the data will be used to formulate a theoretical model based on UNIFAC. A second study is on the kinetics of nucleation and crystal growth by a micro interferometric technique. The development of a model describing the solubilities of complex molecules, of the type to be studied in the proposed research, would lead to significant advances in understanding the behavior of such systems, and it should be of great value in understanding key factors influencing the production of certain pharmaceutical and specialty chemicals in general.

这是生物化合物结晶的基础研究 通过加入有机非溶剂。 研究内容包括： 八种模式氨基酸和两种模式氨基酸溶解度研究 抗生素在不同环境条件下， 将被用来制定一个理论模型的基础上，CNOAC。 一 第二个研究是在成核和晶体生长的动力学， 显微干涉技术 络合物溶解度模型的建立 分子，在拟议的研究中要研究的类型， 导致对这种行为的理解的重大进展， 系统，它应该在理解关键因素方面具有重要价值 影响某些药品和专业的生产 化学品一般。