Rapid Precipitation of Pharmaceuticals and Proteins

药物和蛋白质的快速沉淀

• 批准号: 9510171
• 负责人: Donald Kirwan
• 金额: $ 21.49万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-15 至 2001-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9510171&HistoricalAwards=false
• 关键词: Rapid; Precipitation; Pharmaceuticals; Proteins

CTS-9510171 Donald Kirwan University of Virginia ABSTRACT The aim of the proposed research is to achieve a fundamental understanding of rapid precipitation of pharmaceutical compounds and proteins. Potential applications are in the production of pure, very fine crystalline pharmaceutical products and the recovery of biologically active proteins. The research will focus on measurements of nucleation and crystal growth kinetics, as well as impurity rejection characteristics under high supersaturation conditions. The influence of micromixing on such processes will be investigated along with an evaluation of protein stability during rapid precipitation. The results are expected to have an impact on the development of efficient separation techniques for the pharmaceutical and biotechnology industries.

CTS-9510171 Donald Kirwan弗吉尼亚大学 摘要 拟议研究的目的是实现对药物化合物和蛋白质快速沉淀的基本理解。 潜在的应用是生产纯的、非常精细的结晶药物产品和回收生物活性蛋白质。 研究将集中在成核和晶体生长动力学的测量，以及在高过饱和条件下的杂质排斥特性。 将沿着快速沉淀过程中蛋白质稳定性的评价，研究微量混合对这些过程的影响。 预计这些结果将对制药和生物技术行业有效分离技术的发展产生影响。