Mechanical Power Output of Muscle

肌肉的机械功率输出

• 批准号: 8811347
• 负责人: Robert Josephson
• 金额: $ 27.13万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-10-15 至 1992-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8811347&HistoricalAwards=false
• 关键词: Mechanical; Power; Output; Muscle

The mechanical power output of a striated muscle will be determined by measuring muscle tension as the muscle is subjected to periodic length change and to stimuli which occur at selected phases of the length cycle. The plot of muscle tension against length over a cycle forms a loop whose area is the work done by or on the muscle for that cycle. The goals of this project are: 1) To combine mechanical power measurements from insect wing muscles with simultaneous measurement of oxygen consumption in order to measure the efficiency of the muscle in converting metabolic to mechanical power, and to determine if the operating conditions which maximize power output are also those which maximize efficiency. 2) To extend power measurements to muscles other than insect wing muscles in order to determine how similar or dissimilar are muscles from different sources in their capacity for mechanical power output. 3) To characterize force- velocity curves for both shortening and lengthening muscles at different times after stimulation, and to use this information to create a model which will allow estimation of the power output from a muscle subjected to periodic length change and phasic stimulation. 4) To characterize release inactivation in muscle, and to determine the extent to which release inactivation affects power output during repetitive contraction.

当肌肉受到周期性长度变化以及在长度周期的选定阶段发生的刺激时，横纹肌的机械功率输出将通过测量肌肉张力来确定。 一个周期内肌肉张力与长度的关系图形成一个环，其面积是该周期内肌肉所做的功。 该项目的目标是：1）将昆虫翅膀肌肉的机械功率测量与同时测量的耗氧量结合起来，以测量肌肉将代谢转化为机械功率的效率，并确定最大化功率输出的操作条件是否也是最大化效率的操作条件。 2) 将功率测量扩展到昆虫翅膀肌肉以外的肌肉，以确定不同来源的肌肉在机械功率输出能力方面的相似或不同程度。 3) 表征刺激后不同时间缩短和延长肌肉的力-速度曲线，并使用该信息创建一个模型，该模型将允许估计受到周期性长度变化和阶段性刺激的肌肉的功率输出。 4) 表征肌肉中的释放失活，并确定释放失活对重复收缩期间功率输出的影响程度。