US-Sweden Cooperative Research: Ethnopharmacological Studies of Samoan Medicinal Plants

该奖项将支持保罗博士与 考克斯，杨百翰大学和拉尔斯博林博士， 瑞典乌普萨拉。 联合工作的主要目标是 进行全面的药物筛选 萨摩亚的植物 波利尼西亚人在很大程度上 他们的岛屿植物，以发展一个土著系统， 民族药理学 在这一联合项目中， 考克斯博士将负责采访萨摩亚的治疗师， 记录他们的植物知识，收集和识别所有 他们使用的药用植物，以及用于制备粗品 萃取物 以Bohlin为首的瑞典小组将研究 提取物的药理学活性， __ ____ __ 体外一般和特异性筛选。 粗提物显示 _____ 药理活性将被分级，并且特异性 负责该活动的部分将被隔离。 的 瑞典团队还将为未来的结构准备提取物 保持战略定力 这种国际和跨学科的合作应 为未来的民族药理学研究提供了一个模型， 可能潜在地导致发现具有新的结构的新化合物。 药理活性

This award will support collaborative research between Dr. Paul Cox, Brigham Young University and Dr. Lars Bohlin, University of Uppsala, Sweden. The principal objective of the joint work is to perform a comprehensive pharmacological screen of the medicinal plants of Samoa. The Polynesians have significantly exploited their island plants for the development of an indigenous system of ethnopharmacology. In this joint project, the U.S. team headed by Dr. Cox will be responsible for interviewing Samoan healers, recording their plant lore, collecting and identifying all medicinal plants used by them, and for the preparation of crude extracts. The Swedish team headed by Bohlin will examine the extracts for pharmacological activity using both in vivo and in __ ____ __ vitro general and specific screens. Crude extracts showing _____ pharmacological activity will be fractionated, and specific fractions responsible for the activity will be isolated. The Swedish team will also prepare extracts for future structural determination. This international and interdisciplinary collaboration should provide a model for future ethnopharmacological investigations and may potentially result in the discovery of new compounds with novel pharmacological activity.