Experimental and Theoretical Studies of Vibrational Optical Activity

Timothy Keiderling博士得到了The 实验物理化学计划，继续他的 振动旋光性的应用研究 (VOA)分子化学结构的测定 手性中心。 这项研究具有重要的潜力 作为生物学重要的结构工具的应用 多肽。 Keiderling博士将继续他的开创性工作， 一个活跃的研究领域，重点是使用振动 圆二色性（VCD）的研究小的理论 目标是关联光谱和 结构 还将大力推广 磁振动圆二色性（MVCD） 进一步阐明电子振动耦合在VCD中的作用。 最后，在拉曼领域的仪器改进 圆强度差分（RCID）光谱将使 几种小分子体系的系统实验研究 其中VCD数据先前已经获得。

Dr. Timothy Keiderling is supported by a grant from The Experimental Physical Chemistry Program to continue his research in the application of vibrational optical activity (VOA) to the determination of chemical structures of molecules with chiral centers. This research has important potential applications as a structural tool for biologically important polypeptides. Dr. Keiderling will continue his pioneering work in this active field of research with an emphasis on using vibrational circular dichroism (VCD) studies of small theoretically tractable molecules with a goal of correlating spectra and structure. Intense effort will also be made to generalize previous work on magnetic vibrational circular dichroism (MVCD) to further clarify the role of vibronic coupling in VCD. Finally, instrumental improvements in the area of Raman circular intensity differential (RCID) spectroscopy will enable systematic empirical studies of several small molecule systems for which VCD data have previously been obtained.