Purchase of A Departmental Stopped-Flow Equipped Circular Dichroism Spectrometer

在化学研究仪器和设施（CRIF）计划的支持下，芝加哥伊利诺伊大学化学系将获得一台停流装备圆二色光谱仪。该设备将加强若干领域的研究，包括a）对在溶液中形成β折叠的设计肽的折叠动力学的研究; B）RNA二级和三级结构形成中的快速折叠事件; c）对双链体DNA中序列依赖性背景效应的研究; d）对新型蛋白酶机制的化学生物学研究;以及e）蛋白质和肽折叠和构象研究。 圆二色谱是现代分析化学中一种非常有用的工具。 它提供了一个非常可靠和灵敏的方法来指定绝对分子构型。 这些研究的结果将在许多领域产生影响，特别是生物化学。

With support from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of Illinois in Chicago will acquire a Stopped-Flow Equipped Circular Dichroism Spectrometer. This equipment will enhance research in a number of areas including a) studies on folding kinetics of designed peptides that form beta sheets in solution; b) fast folding events in secondary and tertiary structure formation of RNA; c) studies of sequence dependent context effects in duplex DNA; d) chemical biology studies of novel protease mechanisms; and e) protein and peptide folding and conformational studies. Circular dichroism spectroscopy is an extremely useful tool in modern analytical chemistry. It provides a very reliable and sensitive method for assigning absolute molecular configurations. The results from these studies will have an impact in a number of areas, especially biochemistry.