Purchase of A Departmental Stopped-Flow Equipped Circular Dichroism Spectrometer

购买部门配备停流圆二色性光谱仪

• 批准号: 0091994
• 负责人: Timothy Keiderling
• 金额: $ 11.26万
• 依托单位: University of Illinois at Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-15 至 2004-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0091994&HistoricalAwards=false
• 关键词: Purchase; Departmental; Stopped; Flow; Equipped

With support from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of Illinois in Chicago will acquire a Stopped-Flow Equipped Circular Dichroism Spectrometer. This equipment will enhance research in a number of areas including a) studies on folding kinetics of designed peptides that form beta sheets in solution; b) fast folding events in secondary and tertiary structure formation of RNA; c) studies of sequence dependent context effects in duplex DNA; d) chemical biology studies of novel protease mechanisms; and e) protein and peptide folding and conformational studies. Circular dichroism spectroscopy is an extremely useful tool in modern analytical chemistry. It provides a very reliable and sensitive method for assigning absolute molecular configurations. The results from these studies will have an impact in a number of areas, especially biochemistry.

在化学研究仪器和设施（CRIF）项目的支持下，芝加哥伊利诺伊大学化学系将获得一台配备止流装置的圆二色光谱仪。该设备将加强许多领域的研究，包括a)在溶液中形成β片的设计肽的折叠动力学研究；b) RNA二级和三级结构形成中的快速折叠事件；c)双链DNA序列依赖环境效应的研究；D)新型蛋白酶机制的化学生物学研究；e)蛋白质和肽的折叠和构象研究。圆二色光谱是现代分析化学中一种非常有用的工具。它提供了一种非常可靠和灵敏的方法来确定绝对分子构型。这些研究的结果将对许多领域产生影响，尤其是生物化学。