Defining a role for the survival motor neuron (SMN) protein in the RhoA/ROCK/profilin IIa actin remodeling pathway during neuronal differentiation and in SMA pathogenesis.

定义运动神经元存活 (SMN) 蛋白在神经元分化和 SMA 发病机制中 RhoA/ROCK/profilin IIa 肌动蛋白重塑途径中的作用。

• 批准号: 184423
• 负责人: Bowerman Melissa
• 金额: $ 7.65万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-10-01 至 2011-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=184423&lang=en
• 关键词: Actin Dynamics; Cell Culture; Cytoskeleton; Dna Manipulations; Microscopy; Mouse Models; Neuronal Differentiation; Protein Manipulations; Rna Manipulations; Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is the most common genetic disease resulting in infant mortality. SMA manifests itself due to a severe loss of alpha-motor neurons in the spinal cord of affected individuals. The disease is caused by mutations or deletions o

脊髓性肌萎缩症（SMA）是导致婴儿死亡的最常见的遗传性疾病。SMA表现为受影响个体的脊髓中α运动神经元的严重损失。 这种疾病是由基因突变或缺失引起的。