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Mechanisms of Na and Ca Transport Across the Plasma Membrane of Squid Giant Axons

Mechanisms of Na and Ca Transport Across the Plasma Membrane of Squid Giant Axons
Na 和 Ca 穿过鱿鱼巨轴突质膜的运输机制
批准号:
8817299
负责人:
Luis Beauge
金额:
$6.0万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-07-01 至 1992-12-31

项目摘要

项目成果

Luis Beauge的其他基金

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中文摘要
翻译
Na/Ca交换是一种膜结合机制,负责从细胞中排出净钙。钠/钙交换的重要性是显而易见的,因为它能够挤出大量的钙负荷;然而,这个系统的另一个基本方面是,在某些条件下,它具有“反向”工作的能力,促进了净钙获得和电离ı钙水平的相应增加。在牢房里。这一功能既与生理相关,也与病理相关,因为细胞内钙浓度调节心肌收缩和动脉肌肉收缩。因此,对Na/Ca交换功能的了解有助于深入了解高血压的发生发展机制。本工作旨在进一步表征Na/Ca交换器与载体的不对称性质(对细胞内和细胞外配体的不同反应能力)的关系。目的是确定这种不对称性是系统固有的,还是细胞内和细胞外相周围不同的离子和电环境的结果。这一分析将允许在完整细胞和分离质膜的膜泡中获得的数据之间进行比较,从而拓宽细胞和分子研究的领域。
英文摘要
The Na/Ca exchange is a membrane bound mechanism responsible for net Ca extrusion from the cells. The importance of the Na/Ca exchange is evident from its ability to extrude large Ca loads; however, an additional fundamental aspect of this system results from its capacity, under certain conditions, to work in "reverse" facilitating the net Ca gain and the corresponding increase in the levels of ionized ıCa! of the cell. The relevance of this function is both physiological and pathological, for the intracellular Ca concentrations regulate cardiac muscle contraction and the contraction of the arterial musculature. Therefore, the understanding of the Na/Ca exchange function can provide insights into the mechanisms leading to the development of hypertension. The present work intends to further characterize the Na/Ca exchanger in relation to the asymmetric properties of the carrier (different reactivity towards intra- and extracellular ligands). The aim is to establish if that asymmetry is intrinsic to the system or a consequence of the different ionic and electrical environments surrounding the intra- and extracellular phases of the cell. This analysis will allow a comparison between data obtained in intact cells and in the membrane vesicles from isolated plasma membranes, widening the field of cellular and molecular research.
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Transport and Biochemical Events Associated With Metabolic Regulation of the Squid Nerve Na+/Ca2+ Exchanger
  • 批准号:
    0444598
  • 项目类别:
    Standard Grant
  • 资助金额:
    $19.5万
  • 财政年份:
    2005
  • 负责人:
    Luis Beauge
  • 依托单位:
Na and Ca Transport Across the Plasma Membrane of Squid Giant Axons: Mechanisms of Metabolic Control of the Na/Ca Exchanger
  • 批准号:
    0130962
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $18.79万
  • 财政年份:
    2002
  • 负责人:
    Luis Beauge
  • 依托单位:
Na and Ca Transport Across the Plasma Membrane of Squid Giant Axons: Mechanism of Metabolic Control of the Na/Ca Exchanger
  • 批准号:
    9631107
  • 项目类别:
    Standard Grant
  • 资助金额:
    $12.45万
  • 财政年份:
    1996
  • 负责人:
    Luis Beauge
  • 依托单位:
Mechanisms of Na and Ca Transport Across the Plasma Membranes of Squid Giant Axons, Structure-Function Relationships
  • 批准号:
    9120177
  • 项目类别:
    Standard Grant
  • 资助金额:
    $7.0万
  • 财政年份:
    1992
  • 负责人:
    Luis Beauge
  • 依托单位:
国内基金
海外基金
高压下(Na,K)/(Sr,Ca)合金氢化物结构和超导电 性的理论研究
  • 批准号:
    Q24A040016
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
    宋昊
  • 依托单位:
Si/Al、Si/Ca及Si/Na摩尔比对N-A-S-H和C-A-S-H凝胶固化重金属的性能调控与机理研究
  • 批准号:
    52308235
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    30.00万元
  • 批准年份:
    2023
  • 负责人:
    范程程
  • 依托单位:
N=Z核22Na,40Ca低能库仑激发:电四极矩及跃迁几率精确测量
弓形虫TGME49_287040基因在Na/Ca离子通道中的生物学功能