Modeling and Control of the Crystallization Kinetics of Organic Electrolytes

有机电解质结晶动力学的建模和控制

• 批准号: 8818627
• 负责人: Nair Rodriguez-Hornedo
• 金额: $ 24.88万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-10-01 至 1993-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8818627&HistoricalAwards=false
• 关键词: Modeling; Control; Crystallization; Kinetics; Organic

The proposed research relates to development of principles for engineering the crystallization product of organic electrolyte solutions. Models to describe adequately the nucleation and growth rates and to elucidate precipitation mechanisms of organic electrolytes have been proposed for experimental verification. Emphasis will be placed on developing heuristics for predicting the inclusion of the additives in the precipitate and the role of included additives on the properties of the precipitate crystals. The significance of this research is its relation to the design of solids with carefully engineered physicochemical and biological properties. These properties can dramatically affect the biological activity of pharmaceutical products. It is expected that the goals of the project will be accomplished by studying the precipitation kinetics of a monoprotic acid (diphenylhydantoin) and an amino acid (glutamic acid). The influence of other amino acids and other structurally related additives will be studied from both a structural and a kinetic points of view.

拟议的研究涉及有机电解液结晶产物工程原理的开发。为充分描述有机电解液的成核和生长速率，并阐明有机电解液的沉淀机理，已提出了一些模型以供实验验证。重点将放在开发启发式方法，以预测沉淀物中的添加剂包裹物以及所包含的添加剂对沉淀物晶体性质的作用。这项研究的意义在于它与设计具有精心设计的物理化学和生物特性的固体的关系。这些特性会极大地影响医药产品的生物活性。预计该项目的目标将通过研究一元质酸的沉淀动力学来实现。(二苯海因)和一种氨基酸(谷氨酸)。其他氨基酸和其他结构相关的添加剂的影响将从结构和动力学两个方面进行研究。观点。