The role of CYP26B1-mediated retinoic acid metabolism in regulating osteoblast differentiation in normal bone and heterotopic calcification of cardiovascular tissue

CYP26B1介导的视黄酸代谢在调节正常骨成骨细胞分化和心血管组织异位钙化中的作用

• 批准号: 266647
• 负责人: Petkovich Martin
• 金额: $ 44.3万
• 依托单位: Queen's University (Kingston, Ontario)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-09-01 至 2017-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=266647&lang=en
• 关键词: Bone Remodelling; Bone Repair; Cyp26; Genetic Mouse Model; Osteoblast Differentiation; Osteogenesis; Retinoic Acid Metabolism; Vascular Calcification; Vitamin A

Retinoic acid (RA), the active form of vitamin A, plays an essential role in the formation and maintenance of many tissues both during embryonic development and in the adult. The activity of RA needs to be controlled by mechanisms ensuring that certain ce

视黄酸（RA）是维生素A的活性形式，在胚胎发育和成年期的许多组织的形成和维持中起着重要作用。RA的活动需要通过机制来控制，以确保某些细胞的增殖。