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The role of CYP26B1-mediated retinoic acid metabolism in regulating osteoblast differentiation in normal bone and heterotopic calcification of cardiovascular tissue

The role of CYP26B1-mediated retinoic acid metabolism in regulating osteoblast differentiation in normal bone and heterotopic calcification of cardiovascular tissue
CYP26B1介导的视黄酸代谢在调节正常骨成骨细胞分化和心血管组织异位钙化中的作用
批准号：
266647
负责人：
Petkovich Martin
金额：
$44.3万
依托单位：
Queen's University (Kingston, Ontario)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-09-01 至 2017-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=266647&lang=en
关键词：
Bone Remodelling Bone Repair Cyp26 Genetic Mouse Model Osteoblast Differentiation Osteogenesis Retinoic Acid Metabolism Vascular Calcification Vitamin A

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Retinoic acid (RA), the active form of vitamin A, plays an essential role in the formation and maintenance of many tissues both during embryonic development and in the adult. The activity of RA needs to be controlled by mechanisms ensuring that certain ce
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