Scanning Calorimetry Studies of the Micelle-Vesicle Transition In Phospholipids

已知磷脂和去污剂的混合物经历 胶束和囊泡之间的转换形式在适当的 条件 转换过程发生在 洗涤剂和磷脂组成范围窄 似乎涉及到中间结构， 不同于存在于 过渡区的两个极端边界。 小 已知的过渡的特点， 过渡区及其性质 forms. 本项目涉及几种洗涤剂的研究- 用差示扫描量热法测定磷脂体系. 特别接近过渡区的成分 在胶束和囊泡之间。 磷脂和去污剂的水性混合物中的脂质是 被认为以几种不同的结构形式存在 这取决于溶液中的组成和条件。 在低摩尔比的去污剂脂质单层囊泡 形成，而在高比例胶束结构占主导地位。 的 这些限制结构之间的过渡是一个基本的 对几个重要领域有影响的问题 与物理和化学行为有关的 磷脂 该项目的结果可能是 这对于更好地理解膜重构具有重要意义 方法、囊泡给药方法及其机制 胆汁盐和胆汁酸的胆汁混合物中的脂质转运 磷脂

Mixtures of phospholipid and detergents are known to undergo transformation between micelle and vesicle forms under proper conditions. The transformation process occurs within a narrow range of compositions of detergent and phospholipid and seems to involve intermediate structures which are quite different from either the vesicles or micelles which exist at the two extreme boundaries of the transition region. Little is known about the characteristics of the transitions in the transition region and the properties of the transitions forms. This project involves the study of several detergent- phospholipid systems by differential scanning calorimetry at compositions particularly close to the transition region between micelles and vesicles. Lipids in aqueous mixtures of phospholipids and detergent are thought to exist in several different structural forms dependent upon the composition and conditions in solution. At low mole ratios of detergent to lipid unilamellar vesicles form, while at high ratios micellar structures prevail. The transition between these limiting structures is a fundamental problem that has implications for several important areas relating to the physical and chemical behavior of phospholipids. The results of this project could be significant for a better understanding of membrane reconstitution methods, vesicular drug delivery methods and the mechanisms of lipid transport in biliary mixtures of bile salts and phospholipids.