An RUI-MRI Proposal for the Purchase of a Research Grade NMR

RUI-MRI 关于购买研究级 NMR 的提案

• 批准号: 0079241
• 负责人: Charles Spink
• 金额: $ 21.58万
• 依托单位: SUNY College at Cortland
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0079241&HistoricalAwards=false
• 关键词: RUI; MRI; Proposal; Purchase; Research

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at the State University of New York in Cortland will acquire a 300 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) sodium ion exchange from DNA in the presence of cation ligands; b) rhenium diimine tricarbonyl anion compounds and supramolecular assemblies; c) stereoselective synthesis of tropanes and other heterocyclic amine alkaloids; and d) the stereoselectivity of the 2+2 photodimerization of orotic acid, with implications on the primary mode of solar radiation induced DNA damage carcinogenesis and mutagenesis at the molecular level. In addition, the NMR instrument will be used for coursework in organic chemistry and in the advanced laboratory component of the Chemistry program. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including biochemistry and materials chemistry.

在主要研究仪器（MRI）计划的支持下，位于科特兰的纽约州立大学化学系将获得一台300 MHz NMR光谱仪。该设备将使研究人员能够进行以下研究：a）在阳离子配体存在下从DNA进行钠离子交换; B）三羰基二亚胺阴离子化合物和超分子组装; c）托烷和其他杂环胺生物碱的立体选择性合成;和d）乳清酸的2+2光二聚的立体选择性，在分子水平上对太阳辐射诱导的DNA损伤、致癌和诱变的主要模式有启示。 此外，NMR仪器将用于有机化学课程和化学课程的高级实验室部分。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于从事前沿研究的化学家来说，使用最先进的NMR光谱分析技术是必不可少的。这些NMR研究的结果将在生物化学和材料化学等许多领域产生影响。