Harnessing the human postmortem brain to elucidate changes in FK506 binding protein (FKBP5) in the neuropathology of severe psychiatric disorders

利用人类死后大脑来阐明 FK506 结合蛋白 (FKBP5) 在严重精神疾病神经病理学中的变化

• 批准号: nhmrc : GNT1105445
• 负责人: Dr Natalie Matosin
• 金额: $ 39.21万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/harnessing-human-postmortem-psychiatric-disorders/1346438
• 关键词: Harnessing; human; postmortem; brain; elucidate

The postmortem human brain is a unique source to search for the pathological basis of severe psychiatric disorders including major depression, bipolar disorder and schizophrenia. Postmortem tissues are however being underutilised. This project will apply a selection of powerful biochemical measuring techniques to postmortem human brain tissues to uncover the molecular pathways of severe psychiatric disorders, which is knowledge that can lead to better treatments, preventions and cures.

死后人脑是寻找严重精神疾病（包括重性抑郁症、双相情感障碍和精神分裂症）的病理基础的独特来源。然而，死后组织却没有得到充分利用。该项目将选择强大的生化测量技术应用于死后人脑组织，以揭示严重精神疾病的分子途径，这是可以导致更好的治疗，预防和治愈的知识。