Advanced Experimental Methods: An Integrated Approach

该项目旨在满足在物理、生物和无机化学的界面上新的跨学科方法的需要。建议的实验是专门为介绍现代化学研究的技术和风格而设计的，因为它应用于已被证明与生物相关的分子。为此目的选择了模型体系，包括已被广泛研究的、在配位、催化、电子转移和氧传递等方面具有丰富化学性质的卟啉和金属卟啉化合物。此外，这些化合物的良好记录和合理的光谱性质使它们成为实验室教学的理想选择。学生将使用包括吸收、荧光、IR、核磁共振和ESR光谱在内的几种技术来表征这些分子的结构、结合和氧化还原性质。来自化学共享仪器计划的这项ILI奖将帮助纽约大学化学系获得UV/VIS和IR光谱仪、荧光光谱仪附件以及用于数据采集、数字化和操作的四台PC。该奖项还支持荧光仪、核磁共振和ESR仪器的升级。该仪器将用于加强本科实验室教学，并对化学课程发展产生影响。

This project is designed to meet the needs of new interdisciplinary approaches at the interface of physical, bio-, and inorganic chemistry. The proposed experiments are designed specifically to introduce the techniques and style of modern chemical research as it is applied to molecules of proven biological relevance. For this purpose model systems have been chosen and include porphyrin and metalloporphyrin compounds which have been intensively studied and have rich chemical properties in liganding, catalysis, electron transfer, and oxygen transport. Further, the well documented and rationalized spectroscopic properties of these compounds make them ideal for laboratory instruction. Students will use several techniques including absorption, fluorescence, IR, NMR and ESR spectroscopy to characterize the structure, binding, and redox properties of these molecules. This ILI award from the Chemistry Shared Instrumentation Program will help the Department of Chemistry at New York University to acquire UV/VIS and IR spectrometers, fluorescence spectrometer accessories, and four PC's for data acquisition, digitization and manipulation. Upgrades for a fluorimeter, NMR and ESR instruments are also supported by the award. The instrumentation will be used to enhance undergraduate laboratory instruction and impact on chemistry curriculum development.