A Study of the Bone-Prosthesis Interface by Vibrational Spectroscopy

振动光谱法研究骨-假体界面

• 批准号: 9010607
• 负责人: Marc Walters
• 金额: $ 23.01万
• 依托单位: New York University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1994-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9010607&HistoricalAwards=false
• 关键词: Study; Bone; Prosthesis; Interface; Vibrational

This is an application to study spectroscopically the mineral coating of composite prosthetic implants. The hypothesis is that the nature of the bone-implant interface is determined by the nature of the implant surface whether or not the interface is occupied by mineralized or non-mineralized tissue. The hypothesis will be tested using animal experiments. The primary tool for surface characterization is Raman spectroscopy; spectral resolution will be enhanced by 2nd derivative computations. This study will provide basic information about the interface between bone and various calcium mineral coatings. The gained knowledge should be very useful for designing optimized mineral coatings for implants.

这是一种应用光谱研究复合假体植入物矿物涂层的方法。假设骨-种植体界面的性质是由种植体表面的性质决定的，无论界面是否被矿化或非矿化组织所占据。这一假设将通过动物实验进行验证。表面表征的主要工具是拉曼光谱；二阶导数计算将提高光谱分辨率。本研究将为研究骨与各种钙矿物涂层之间的界面提供基础信息。所获得的知识对于设计最佳的种植体矿物涂层是非常有用的。