Presidential Young Investigator Award: Molecular Recognition and Biomimetic Chemistry

总统青年研究员奖：分子识别和仿生化学

• 批准号: 8858202
• 负责人: Steven Zimmerman
• 金额: $ 31.2万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-15 至 1993-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8858202&HistoricalAwards=false
• 关键词: Presidential; Young; Investigator; Award; Molecular

This Presidential Young Investigator Award given in the Organic and Macromolecular Chemistry Program provides support for the work of Dr. Steven Zimmerman, University of Illinois. This work is focused on two areas of mechanistic bioorganic chemistry: (1) the molecular recognition of DNA and (2) biomimetic chemistry. Molecular recognition of DNA will allow probes to be developed which selectively bind to DNA. These subsequently will provide the means for changing the properties of DNA so subtle alterations in its design can be made. Biomimetic studies will allow a better understanding of the various aspects of enzymatic catalysis. More specifically, molecular "tweezers" are being prepared which are expected to bind exclusively at the end of DNA helices or at structural abnormalities such as the proposed beta-kink site. In addition, major groove intercalators are being investigated. Biomimetic studies have produced a stereoelectronically correct charge relay model for chymotrypsin which is currently being studied in detail.

这项在有机和高分子化学项目中颁发的总统青年研究人员奖为伊利诺伊大学的Steven Zimmerman博士的工作提供了支持。这项工作集中在机械生物有机化学的两个领域：(1)DNA的分子识别和(2)仿生化学。DNA的分子识别将使人们能够开发出选择性地与DNA结合的探针。这些随后将提供改变DNA属性的方法，以便在其设计中进行细微的改变。仿生学研究将使人们更好地了解酶催化的各个方面。更具体地说，正在研制的分子“镊子”有望仅结合在DNA螺旋的末端或结构异常处，如拟议的β-扭结部位。此外，正在研究主要的凹槽嵌入器。仿生研究已经为凝乳酶产生了一个立体电子正确的电荷继电器模型，目前正在进行详细的研究。