A New Approach to Functionalized Organic and Metal Nanoparticles

功能化有机和金属纳米颗粒的新方法

• 批准号: 1307404
• 负责人: Steven Zimmerman
• 金额: $ 37.06万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1307404&HistoricalAwards=false
• 关键词: New; Approach; Functionalized; Organic; Metal

In this project funded by the Macromolecular, Supramolecular, and Nanochemistry Program of the Chemistry Division, Steven C. Zimmerman of the University of Illinois will create a new method for preparing organic nanoparticles. The approach involves the ring-opening metathesis polymerization of a functionalized monomer followed by an extensive series of intra-particle cross-linking reactions. The organic nanoparticles to be developed are fundamentally different than previously described (e.g., dendrimers, nanocrystals, molecular assemblies, etc.) because through the synthesis their size can be controlled from 1 to 100 nanometers and their flexibility is full tunable by controlling the extent of cross-linking. The chemistry is also sufficiently flexible to allow the synthesis of two-part or Janus organic nanoparticles and to allow one or more attachments to the surface and interior of the organic nanoparticle. The broader impacts involve training undergraduate and graduate students, broadening participation through the inclusion of research personnel from groups underrepresented in the chemical science, and continuing a research apprenticeship program for underrepresented minority students at the University of Illinois, Department of Chemistry.Nanoparticles are materials whose dimensions fall into the range of 1-100 nanometers and have many potential applications including supports for chemical synthesis, light harvesting antennae, platforms for new biomedical imaging agents, and drug encapsulation and triggered release systems. This project aims to study how nanoparticles can be prepared with a very high degree of control over their size and chemical characteristics. The nanoparticles to be studied in this project are made from organic precursors and are expected to be nontoxic and have minimal environmental impact.

在这个由化学部门的大分子、超分子和纳米化学项目资助的项目中，伊利诺伊大学的Steven C. Zimmerman将创造一种制备有机纳米粒子的新方法。该方法涉及一个功能化单体的开环复分解聚合，随后是一系列广泛的颗粒内交联反应。要开发的有机纳米颗粒与先前描述的（例如，树状大分子，纳米晶体，分子组装等）有根本不同，因为通过合成，它们的尺寸可以控制在1到100纳米之间，并且通过控制交联的程度可以完全调节它们的灵活性。化学反应也足够灵活，可以合成两部分或双面有机纳米颗粒，并允许一个或多个附着在有机纳米颗粒的表面和内部。更广泛的影响包括培训本科生和研究生，通过纳入化学科学中代表性不足的群体的研究人员来扩大参与，以及继续为伊利诺伊大学化学系代表性不足的少数民族学生提供研究学徒计划。纳米颗粒是一种尺寸在1-100纳米之间的材料，具有许多潜在的应用，包括支持化学合成、光收集天线、新型生物医学显像剂平台、药物封装和触发释放系统。该项目旨在研究如何在高度控制纳米颗粒大小和化学特性的情况下制备纳米颗粒。在这个项目中研究的纳米颗粒是由有机前体制成的，预计是无毒的，对环境的影响最小。