An Engineering Approach to Microcarrier Surface Design

微载体表面设计的工程方法

• 批准号: 8860640
• 负责人: Michael Manning
• 金额: $ 5万
• 依托单位: Tekmat Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-01-01 至 1989-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8860640&HistoricalAwards=false
• 关键词: Engineering; Approach; Microcarrier; Surface; Design

The long range goal of this project is to develop polymer based microcarriers with novel surfaces which will support the growth of cells otherwise difficult or impossible to grow in vitro. These supports will be useful in small scale laboratory cell culture and will be easily adpatable to the large scale, highly efficient manufacture of cells and other tissue culture products. The proposed research will allow alteration of the microcarrier surface, independent of its bulk properties, without the necessity of post-treatment. This will be accomplished by modifying well- known suspension polymerization techniques to produce microcarrier beads with the desired surface chemical functionalities. In addition, the versatility of the supports and their manufacture will enable the creation of optimal growth surfaces for a wide variety of cells.

该项目的长期目标是开发具有新颖表面的聚合物微载体，以支持细胞的生长，否则很难或不可能在体外生长。这些载体将在小规模实验室细胞培养中有用，并将容易适用于大规模、高效的细胞和其他组织培养产品的生产。拟议的研究将允许改变微载体的表面，而与其整体性质无关，而不需要进行后处理。这将通过修改众所周知的悬浮聚合技术来实现，以生产具有所需表面化学功能的微载体微珠。此外，载体及其制造的多功能性将能够为各种细胞创造最佳的生长表面。