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In situ characterization of MeCP2-containing chromatin domains

In situ characterization of MeCP2-containing chromatin domains
含有 MeCP2 的染色质结构域的原位表征
批准号:
279671
负责人:
Ausio Juan
金额:
$38.13万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-03-01 至 2018-03-01

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中文摘要
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英文摘要
Rett syndrome is a slow progressing neurodevelopmental disease,that affects approximately 1 in 10,000 infant females. 85% of the clinical cases have been traced to mutations of MeCP2, a vital regulatory protein that cannot function properly when mutated,
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Role of global post-translational modifications, histone variants and linker histones in chromatin folding and function.
Role of global post-translational modifications, histone variants and linker histones in chromatin folding and function.
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