Collection of Mutant Types of Drosophila melanogaster

原来设在加州理工学院的果蝇股票中心已转移到位于布鲁明顿的印第安纳大学，股票中心作为国际研究界的资源的作用得到了扩大。该库存中心目前保存了3000多个不同遗传特征的果蝇品系，以及以前保存的100多个品系。1988年，处理了638个关于储存和/或信息的请求，导致从印第安纳州收集的2667株菌株的传代培养物被运送给25个国家的研究人员。除了扩大收集的内容外，还建立了一个计算机化的数据库，帮助调查人员快速确定从库存中心获得的哪些菌株可能与他们的个别研究项目相关。当需要从库存中心获得菌株时，尽可能提供有关所需材料的可能来源的信息。按照加州理工学院股票中心的传统，印第安纳州股票中心继续构建作为各种研究项目基本工具的果蝇和果蝇品系。牲畜中心的工作人员还为研究社区提供有关成功饲养和对这一重要研究有机体进行基因操作的信息来源。人类基因组测序的国家研究计划将通过使用模式系统的开创性研究来促进，如a&gt；果蝇&gt；。这种简单的真核生物有很长的遗传用途历史，因此比任何其他后生动物更了解它的基因组结构。这一事实加上较小的基因组大小，使得&gt；果蝇&gt；成为建立用于人类基因组计划的范例的各个方面的理想候选者。股票中心作为培养维护和信息交换中心的双重角色，将促进这种微生物的使用，供刚接触&gt；果蝇&>t；的研究人员以及研究人员使用。该项目为股票中心今后五年的活动提供部分支持。

The >Drosophila> Stock Center previously housed at the California Institute of Technology has been transferred to Indiana University at Bloomington, where the Stock Center's role as a resource to the international research community has been expanded. The Stock Center currently maintains over 3000 genetically distinct strains of the fruit fly >ÕDrosophila> >melanogaster> plus over 100 strains previously maintained. In 1988, 638 requests for stocks an/or information were processed, resulting in the shipment of 2667 subcultures of strains from the Indiana collection to researchers in 25 countries. In addition to expanding the content of the collection, a computerized database has been established that assists investigators in rapidly determining which strains available from the Stock Center are likely to be relevant to their individual research programs. When strains not available from the Stock Center are requested, information about likely sources of the desired materials is provided whenever possible. In the tradition of the Caltech Stock Center, >Drosophila> strains that serve as basic tools in a wide variety of research projects continue to be constructed at the Indiana Stock Center. Stock Center personnel also serve the research community as a source of information about successful husbandry and genetic manipulation of this important research organism. The national research initiative for the sequencing of the human genome will be facilitated by pioneering studies using model systems such a >Drosophila>. This simple eukaryote has a long history of genetic utility and thus much more is known about its genomic structure than any other metazoan. This fact coupled with the small genome size makes >Drosophila> an ideal candidate for establishing aspects of the paradigm to be used in the human genome project. The Stock Center, in its dual role of culture maintenance and informational clearing house, will facilitate the use of this organism by researchers new to >Drosophila> as well as the cognoscenti. This project provides partial support for the Stock Centers activities for the next five years.