Collection of Mutant Types of Drosophila melanogaster

黑腹果蝇突变类型的收集

• 批准号: 8901754
• 负责人: Thomas Kaufman
• 金额: $ 109.16万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-15 至 1994-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8901754&HistoricalAwards=false
• 关键词: Collection; Mutant; Types; Drosophila; melanogaster

The >Drosophila> Stock Center previously housed at the California Institute of Technology has been transferred to Indiana University at Bloomington, where the Stock Center's role as a resource to the international research community has been expanded. The Stock Center currently maintains over 3000 genetically distinct strains of the fruit fly >ÕDrosophila> >melanogaster> plus over 100 strains previously maintained. In 1988, 638 requests for stocks an/or information were processed, resulting in the shipment of 2667 subcultures of strains from the Indiana collection to researchers in 25 countries. In addition to expanding the content of the collection, a computerized database has been established that assists investigators in rapidly determining which strains available from the Stock Center are likely to be relevant to their individual research programs. When strains not available from the Stock Center are requested, information about likely sources of the desired materials is provided whenever possible. In the tradition of the Caltech Stock Center, >Drosophila> strains that serve as basic tools in a wide variety of research projects continue to be constructed at the Indiana Stock Center. Stock Center personnel also serve the research community as a source of information about successful husbandry and genetic manipulation of this important research organism. The national research initiative for the sequencing of the human genome will be facilitated by pioneering studies using model systems such a >Drosophila>. This simple eukaryote has a long history of genetic utility and thus much more is known about its genomic structure than any other metazoan. This fact coupled with the small genome size makes >Drosophila> an ideal candidate for establishing aspects of the paradigm to be used in the human genome project. The Stock Center, in its dual role of culture maintenance and informational clearing house, will facilitate the use of this organism by researchers new to >Drosophila> as well as the cognoscenti. This project provides partial support for the Stock Centers activities for the next five years.

>Drosophila> Stock Center以前位于 加州理工学院已被转移到 位于布卢明顿的印第安纳州大学，股票中心的作用 作为国际研究界的资源， 扩大 股票中心目前维持超过3000 遗传上不同的果蝇品系>果蝇属> >黑腹菌>加上以前维持的100多个菌株。 在 1988年，处理了638项索取库存和/或资料的请求， 导致2667个菌株的继代培养物从 印第安纳州的收藏品提供给25个国家的研究人员。 此外 扩大收藏的内容，一个计算机化的 建立了一个数据库，协助调查人员 快速确定库存中心提供的菌株 可能与他们的个人研究项目有关。 当需要库存中心无法提供的菌株时， 有关所需材料可能来源的信息 尽可能提供。 按照加州理工学院的传统 股票中心，>果蝇>菌株，作为基本工具，在一个 各种各样的研究项目继续建设， 印第安纳州股票中心 股票中心人员还服务于 研究社区作为成功的信息来源 畜牧业和遗传操作这一重要研究 有机体 国家研究计划的测序 人类基因组将通过使用 模型系统，如>果蝇>。 这种简单的真核生物有一个 遗传效用的悠久历史，因此更多地了解 它的基因组结构比任何其他后生动物都要复杂。 这一事实加上 小基因组大小使>果蝇>成为理想的候选者 用于建立用于人类的范式的各个方面， 基因组计划。 股票中心，在其文化的双重作用 维护和信息交换所，将促进 新研究果蝇的研究人员也使用了这种生物体， as the cognoscenti. 该项目为库存中心提供部分支持 未来五年的活动。