Collection of Mutant Types of Drosophila melanogaster

此前位于加州理工学院的>果蝇>库存中心已经转移到位于布卢明顿的印第安纳大学，在那里，库存中心作为国际研究界的资源的作用得到了扩大。库存中心目前保存着3000多种基因不同的果蝇>ÕDrosophila> >黑腹果蝇>以及之前保存的100多种菌株。1988年，处理了638个库存和/或信息请求，导致从印第安纳州收集的2667个菌株亚种运往25个国家的研究人员。除了扩大收集的内容外，还建立了一个计算机化的数据库，帮助研究人员迅速确定从库存中心获得的哪些菌株可能与他们的个人研究计划有关。当需要库存中心无法提供的品种时，尽可能提供所需材料可能来源的信息。在加州理工学院股票中心的传统中，作为各种研究项目的基本工具的>果蝇菌株继续在印第安纳股票中心建设。库存中心的工作人员还为研究社区提供有关这种重要研究生物的成功饲养和遗传操作的信息来源。使用b>果蝇>等模型系统的开创性研究将促进人类基因组测序的国家研究计划。这种简单的真核生物具有悠久的遗传效用历史，因此对其基因组结构的了解比任何其他后生动物都要多。这一事实加上较小的基因组大小使>果蝇成为建立范例方面的理想候选者，用于人类基因组计划。该库存中心具有培养维护和信息交换的双重作用，将促进新接触果蝇b>的研究人员和专家使用这种生物。该项目为库存中心今后五年的活动提供部分支助。

The >Drosophila> Stock Center previously housed at the California Institute of Technology has been transferred to Indiana University at Bloomington, where the Stock Center's role as a resource to the international research community has been expanded. The Stock Center currently maintains over 3000 genetically distinct strains of the fruit fly >ÕDrosophila> >melanogaster> plus over 100 strains previously maintained. In 1988, 638 requests for stocks an/or information were processed, resulting in the shipment of 2667 subcultures of strains from the Indiana collection to researchers in 25 countries. In addition to expanding the content of the collection, a computerized database has been established that assists investigators in rapidly determining which strains available from the Stock Center are likely to be relevant to their individual research programs. When strains not available from the Stock Center are requested, information about likely sources of the desired materials is provided whenever possible. In the tradition of the Caltech Stock Center, >Drosophila> strains that serve as basic tools in a wide variety of research projects continue to be constructed at the Indiana Stock Center. Stock Center personnel also serve the research community as a source of information about successful husbandry and genetic manipulation of this important research organism. The national research initiative for the sequencing of the human genome will be facilitated by pioneering studies using model systems such a >Drosophila>. This simple eukaryote has a long history of genetic utility and thus much more is known about its genomic structure than any other metazoan. This fact coupled with the small genome size makes >Drosophila> an ideal candidate for establishing aspects of the paradigm to be used in the human genome project. The Stock Center, in its dual role of culture maintenance and informational clearing house, will facilitate the use of this organism by researchers new to >Drosophila> as well as the cognoscenti. This project provides partial support for the Stock Centers activities for the next five years.