Collection of Mutant Types of Drosophila melanogaster

该奖项为布卢明顿果蝇库存中心提供了新的支持，该中心收集、维护和分发普通果蝇黑腹果蝇的遗传标记库存。 在昆虫和脊椎动物中观察到的蛋白质、细胞和发育途径的高度保守性，加上广泛的一套发达的遗传工具，使果蝇成为研究生物学基本问题的最重要的模式生物之一。 布卢明顿库存中心收藏的大量基因确定的菌株已成为利用果蝇进行现代研究的关键资源。 该集合由超过12，500种不同的遗传库存组成，大多数遗传标记为可见，致命或不育突变（占集合的41%），其他等位基因（11%），染色体畸变（20%）或转座子插入（18%）。 其余10%为特殊用途储存（10%），包括用于快速绘图的储存。 关于种群的信息被纳入果蝇群落的主要数据库FlyBase，并可从该中心的网站上查阅。 这使用户群体能够充分获得关于收藏品中现有股票的最新信息。 此外，中心的科学家可以回答问题，并提供有关使用这些材料的建议。 收藏中的菌株需求量很大，平均每年向中心请求115，000份库存。 学术研究人员收到了95%以上的样本。 这一资源有助于科学进步，确保所有研究人员都能随时获得具有当前研究价值的各种各样的记录菌株，并通过信息服务促进有效利用现有的研究材料。 果蝇资源活动影响了利用果蝇研究的所有研究领域。 其中包括基因调控，细胞生物学，发育生物学，神经生物学，行为生物学，种群生物学，生态学和进化。

This award provides renewed support for the Bloomington Drosophila Stock Center, which collects, maintains, and distributes genetically marked stocks of the common fruit fly Drosophila melanogaster. The high degree of conservation of proteins and of cellular and developmental pathways observed among insects and vertebrates, in combination with an extensive set of well developed genetic tools, has made the fruit fly one of the foremost model organisms for investigation of fundamental problems in biology. The extensive collection of genetically defined strains housed at the Bloomington Stock Center has become a critical resource for modern research using Drosophila. The collection consists of over 12,500 different genetic stocks, most genetically marked with visible, lethal or sterile mutations (41% of the collection), other alleles (11%), chromosome aberrations (20%), or transposon insertions (18%). The remaining 10% consist of special-purpose stocks (10%), including those used for rapid mapping. Information about stocks is incorporated into FlyBase, the primary Drosophila community database, and is available from the Center's web site. This provides the community of users with full access to up-to-date information about stocks available from the collection. In addition, Center scientists are available to answer questions and provide advice on the use of these materials. Strains in the collection are in demand, with an average of 115,000 stocks a year requested from the Center. Academic researchers receive over 95% of the samples distributed. This resource contributes to scientific progress by assuring that a wide variety of documented strains of current research value are readily available to all researchers, and by promoting the effective use of available research materials through information services. Drosophila resource activities impact all areas of research that make use of Drosophila studies. Among others, these include gene regulation, cell biology, developmental biology, neurobiology, behavioral biology, population biology, ecology and evolution.