Stereo- and Enantioselective Synthesis with Fluorinated Reagents

约翰·韦尔奇的研究得到了合成有机化学项目的支持。韦尔奇是化学副教授，他正在研究制造含氟有机化合物的新方法。他的方法的特点是，目标是制备含有氟的小而简单的分子，同时又具有独特的能力，可以很容易地结合到更大、更复杂的分子中。韦尔奇还在开发能够制备手性含氟分子的方法。将开发利用简单、廉价、非手性的单氟化物进行非对映选择性和对映体选择性合成单氟化物的一般方法。不对称性和功能性是通过这些氟化构建块的碳-碳键形成反应或重排来引入的。将探索ı3，3！-Sigmatrotic重排反应在氟化酮缩醛反应中的基本用途。作为制备烯丙基氟酮的手段，新的含氟烯胺化学将被研究。有机金属化学的铬氟化卡宾络合物作为一种手段，以制备氟内酰胺。

The research of John Welch is supported by the Synthetic Organic Chemistry Program. Welch, associate professor of chemistry, is studying new ways to make organic compounds that contain fluorine. His approach is characterized by the goal to prepare small, simple molecules that contain fluorine that also have the unique ability to be readily incorporated into larger, more complex molecules. Welch is also developing methods by which chiral fluorine containing molecules can be prepared. General methods for the diastereo- and enantioselective synthesis of monofluorinated materials by using simple, inexpensive, achiral monofluorinated compounds will be developed. Asymmetry and functionality are introduced using the carbon-carbon bond forming reactions or rearrangements of these fluorinated building blocks. The fundamental utility of ı3,3!-sigmatropic rearrangements of fluorinated ketene acetals will be explored. Novel new chemistry of fluorinated enamines will be investigated as means to prepare allyated fluorinated ketones. Organometallic chemistry of chromium fluorinated carbene complexes as a means to prepare fluorinated lactams will be examined.