Stereo- and Enantioselective Synthesis with Fluorinated Reagents

使用氟化试剂进行立体选择性和对映选择性合成

• 批准号: 8901986
• 负责人: John Welch
• 金额: $ 18.17万
• 依托单位: SUNY at Albany
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-15 至 1993-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8901986&HistoricalAwards=false
• 关键词: Stereo; Enantioselective; Synthesis; Fluorinated; Reagents

The research of John Welch is supported by the Synthetic Organic Chemistry Program. Welch, associate professor of chemistry, is studying new ways to make organic compounds that contain fluorine. His approach is characterized by the goal to prepare small, simple molecules that contain fluorine that also have the unique ability to be readily incorporated into larger, more complex molecules. Welch is also developing methods by which chiral fluorine containing molecules can be prepared. General methods for the diastereo- and enantioselective synthesis of monofluorinated materials by using simple, inexpensive, achiral monofluorinated compounds will be developed. Asymmetry and functionality are introduced using the carbon-carbon bond forming reactions or rearrangements of these fluorinated building blocks. The fundamental utility of ı3,3!-sigmatropic rearrangements of fluorinated ketene acetals will be explored. Novel new chemistry of fluorinated enamines will be investigated as means to prepare allyated fluorinated ketones. Organometallic chemistry of chromium fluorinated carbene complexes as a means to prepare fluorinated lactams will be examined.

约翰·韦尔奇的研究得到了合成有机化学项目的支持。化学副教授韦尔奇正在研究制造含氟有机化合物的新方法。他的方法的特点是，目标是制备含有氟的小而简单的分子，这些分子又具有独特的能力，可以很容易地结合到更大、更复杂的分子中。韦尔奇还在开发制备手性含氟分子的方法。将开发利用简单、廉价的非手性单氟化合物进行非映对和对映选择性合成单氟材料的一般方法。不对称性和功能性是通过碳-碳键形成反应或这些氟化构建块的重排来引入的。ı3的基本用途，3！探讨氟化烯酮缩醛的符号位重排。本文将研究新型的氟化胺化学反应，以制备烯丙化氟酮。研究了氟化铬羰基配合物制备氟化内酰胺的有机金属化学性质。