Stereo- and Enantioselective Synthesis with Fluorinated Reagents

约翰·韦尔奇的研究得到了《合成》杂志的支持。 有机化学课程。 韦尔奇，副教授， 化学，正在研究新的方法来制造有机化合物， 含有氟。 他的方法的特点是， 制备含有氟的小而简单的分子， 具有独特的能力， 更复杂的分子。 韦尔奇也在开发方法， 所述手性含氟分子可被制备。 非对映体和对映体选择性的一般方法 通过使用简单， 廉价的非手性单氟化化合物将被 开发 不对称性和功能性是使用 碳-碳键形成反应或重排 这些氟化的结构单元。 的基本效用 三，三！氟化乙烯酮缩醛的σ迁移重排 将被探索。 氟化烯胺的新化学 将被研究作为制备烯丙基化氟化的手段， 酮。 氟化铬的有机化学 作为制备氟化内酰胺的手段的碳烯络合物 将被审查。

The research of John Welch is supported by the Synthetic Organic Chemistry Program. Welch, associate professor of chemistry, is studying new ways to make organic compounds that contain fluorine. His approach is characterized by the goal to prepare small, simple molecules that contain fluorine that also have the unique ability to be readily incorporated into larger, more complex molecules. Welch is also developing methods by which chiral fluorine containing molecules can be prepared. General methods for the diastereo- and enantioselective synthesis of monofluorinated materials by using simple, inexpensive, achiral monofluorinated compounds will be developed. Asymmetry and functionality are introduced using the carbon-carbon bond forming reactions or rearrangements of these fluorinated building blocks. The fundamental utility of ı3,3!-sigmatropic rearrangements of fluorinated ketene acetals will be explored. Novel new chemistry of fluorinated enamines will be investigated as means to prepare allyated fluorinated ketones. Organometallic chemistry of chromium fluorinated carbene complexes as a means to prepare fluorinated lactams will be examined.