Stereo- and Enantioselective Synthesis with Fluorinated Reagents

约翰·韦尔奇的研究得到了合成有机化学项目的支持。 韦尔奇是化学副教授，他正在研究制造含氟有机化合物的新方法。 他的方法的特点是目标是制备含氟的小而简单的分子，这些分子还具有易于掺入更大、更复杂的分子的独特能力。 韦尔奇还在开发制备手性含氟分子的方法。 将开发使用简单、廉价、非手性单氟化化合物非对映和对映选择性合成单氟化材料的通用方法。 利用这些氟化结构单元的碳-碳键形成反应或重排引入不对称性和功能性。 将探索氟化烯酮缩醛的 ı3,3!-σ 重排的基本用途。 将研究氟化烯胺的新化学作为制备烯丙基化氟化酮的方法。 将检查铬氟化卡宾络合物作为制备氟化内酰胺的方法的有机金属化学。

The research of John Welch is supported by the Synthetic Organic Chemistry Program. Welch, associate professor of chemistry, is studying new ways to make organic compounds that contain fluorine. His approach is characterized by the goal to prepare small, simple molecules that contain fluorine that also have the unique ability to be readily incorporated into larger, more complex molecules. Welch is also developing methods by which chiral fluorine containing molecules can be prepared. General methods for the diastereo- and enantioselective synthesis of monofluorinated materials by using simple, inexpensive, achiral monofluorinated compounds will be developed. Asymmetry and functionality are introduced using the carbon-carbon bond forming reactions or rearrangements of these fluorinated building blocks. The fundamental utility of ı3,3!-sigmatropic rearrangements of fluorinated ketene acetals will be explored. Novel new chemistry of fluorinated enamines will be investigated as means to prepare allyated fluorinated ketones. Organometallic chemistry of chromium fluorinated carbene complexes as a means to prepare fluorinated lactams will be examined.