Inert-Transition Metal-Phosphate Complexes: Synthesis, Structure and Reactivity (Chemistry)

生命系统的大部分能量货币储存在磷酸二酯键中，并通过金属催化的磷酸水解释放出来。因此，了解金属-磷酸键的性质和金属促进的磷酸水解酶的机理是非常重要的。替代惰性过渡金属，如Co和Rh，作为生物活性金属的模型体系是非常有价值的，这些金属太不稳定，无法进行结构和机理研究。Rh(III)相对于Co(III)的两个主要优点是：Rh(III)的络合物是非常惰性的，应该可以让我们分离和表征已提出的用于Co(III)体系的反应中间体的类似物。其次，Rh将通过直接观察103Rh核和与系统中的其他核耦合，在核磁共振研究中提供重要的结构和机制信息。托雷斯博士将合成、分离和表征ı！型RhLnPx！式中L=配体P=具有一、二、三磷酸配体和具有核苷酸(ANP、GNP、CNP和UNP)的磷酸盐。她将阐明磷酸盐-金属配位，并分离和表征磷酸水解反应中的关键中间体。Torres博士将讲授高级无机和生物无机化学课程，并通过研究生院化学系和妇女研究项目组织研讨会。来自工业、政府和学术界的女性化学家将被邀请向本科生介绍她们的研究工作，并讨论女性在科学领域的职业机会和选择。此外，她还将与亚特兰大的美国化学学会妇女分会合作，开展青年(初中和高中)活动计划。该项目进一步推动了VPW计划的目标，即：(1)为妇女提供机会，在NSF资助的工程和科学学科中发展她们的职业生涯；(2)通过提高受雇于工业、政府和学术机构的女科学家和工程师的知名度，鼓励妇女追求科学和工程事业。通过鼓励妇女参与科学，这是对国家未来科学活力的宝贵投资。

A large part of the energy currency of living systems is stored in phosphodiester bonds and released through metal-catalyzed phosphate hydrolysis. Thus, it is of fundamental importance to understand the nature of metal-phosphate bonding and the mechanism of metal-promoted phosphate hydrolysis. Substitution inert transition metals such as Co and Rh are extremely valuable as model systems of the biologically active metals which are too labile for structural and mechanistic studies. Two key advantages of Rh(III) over Co(III) are the following: Rh(III) complexes are extremely inert and should allow us to isolate and characterize analogs of reaction intermediates which have been proposed for the Co(III) systems. Second, Rh will provide important structural and mechanistic information in NMR studies both by direct observation of the 103Rh nucleus and by coupling to other nuclei in the system. Dr. Torres will synthesize, isolate and characterize Rh(III) complexes of the type ıRhLnPx! where L=ligand P=phosphate with mono-, di-, and triphosphate ligands and with nucleotides (ANP, GNP, CNP and UNP). She will elucidate the phosphate-metal coordination and isolate and characterize key intermediates in the phosphate hydrolysis reaction. Dr. Torres will lecture in the advanced inorganic and bioinorganic chemistry courses and organize a symposium through the Chemistry Department and the Women's Studies program of the Graduate Institute. Female chemists from industry, government and academia will be invited to present their research work to undergraduate students, and to discuss career opportunities and choices for women in science. In addition, she will collaborate with the Women's Section of the American Chemical Society in Atlanta in their youth (junior and senior high school) activities program. This project furthers VPW program objectives which are (1) to provide opportunities for women to advance their careers in engineering and in the disciplines of science supported by NSF and (2) to encourage women to pursue careers in science and engineering by providing greater visibility for women scientists and engineers employed in industry, government, and academic institutions. By encouraging the participation of women in science, it is a valuable investment in the Nation's future scientific vitality.