Inert-Transition Metal-Phosphate Complexes: Synthesis, Structure and Reactivity (Chemistry)

惰性过渡金属磷酸盐配合物：合成、结构和反应性（化学）

• 批准号: 8903143
• 负责人: Lourdes Torres
• 金额: $ 9.15万
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1991-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8903143&HistoricalAwards=false
• 关键词: Inert; Transition; Metal; Phosphate; Complexes

A large part of the energy currency of living systems is stored in phosphodiester bonds and released through metal-catalyzed phosphate hydrolysis. Thus, it is of fundamental importance to understand the nature of metal-phosphate bonding and the mechanism of metal-promoted phosphate hydrolysis. Substitution inert transition metals such as Co and Rh are extremely valuable as model systems of the biologically active metals which are too labile for structural and mechanistic studies. Two key advantages of Rh(III) over Co(III) are the following: Rh(III) complexes are extremely inert and should allow us to isolate and characterize analogs of reaction intermediates which have been proposed for the Co(III) systems. Second, Rh will provide important structural and mechanistic information in NMR studies both by direct observation of the 103Rh nucleus and by coupling to other nuclei in the system. Dr. Torres will synthesize, isolate and characterize Rh(III) complexes of the type ıRhLnPx! where L=ligand P=phosphate with mono-, di-, and triphosphate ligands and with nucleotides (ANP, GNP, CNP and UNP). She will elucidate the phosphate-metal coordination and isolate and characterize key intermediates in the phosphate hydrolysis reaction. Dr. Torres will lecture in the advanced inorganic and bioinorganic chemistry courses and organize a symposium through the Chemistry Department and the Women's Studies program of the Graduate Institute. Female chemists from industry, government and academia will be invited to present their research work to undergraduate students, and to discuss career opportunities and choices for women in science. In addition, she will collaborate with the Women's Section of the American Chemical Society in Atlanta in their youth (junior and senior high school) activities program. This project furthers VPW program objectives which are (1) to provide opportunities for women to advance their careers in engineering and in the disciplines of science supported by NSF and (2) to encourage women to pursue careers in science and engineering by providing greater visibility for women scientists and engineers employed in industry, government, and academic institutions. By encouraging the participation of women in science, it is a valuable investment in the Nation's future scientific vitality.

生命系统的大部分能量都储存在 磷酸二酯键，并通过金属催化的磷酸盐释放 水解 因此，了解 金属-磷酸盐键合的本质和金属促进的 磷酸盐水解 取代惰性过渡金属如Co 和Rh作为生物学的模型系统是非常有价值的。 对于结构和机械来说太不稳定的活性金属 问题研究 Rh（III）相对于Co（III）的两个关键优势是 Rh（III）配合物是非常惰性的，应该允许我们 分离和表征反应中间体的类似物， 已被提议用于Co（III）系统。 第二，Rh将提供 核磁共振研究中重要结构和机理信息 通过直接观察103 Rh核并与其他核耦合， 系统中的原子核。 托雷斯博士会合成，分离， 表征Rh（III）类型的配合物<$RhLnPx！其中L=配体 P=具有单-、二-和三磷酸酯配体的磷酸酯，以及具有 核苷酸（ANP、GNP、CNP和UNP）。 她将阐明 磷酸盐-金属配位、分离和表征关键 磷酸盐水解反应中的中间体。 托雷斯博士将在先进的无机和生物无机讲座 化学课程，并通过化学组织研讨会 研究生院妇女研究系和妇女研究方案。 将邀请来自工业界、政府和学术界的女化学家参加 向本科生介绍他们的研究工作，并 讨论女性在科学领域的职业机会和选择。 在 此外，她还将与妇女科合作， 美国化学学会在亚特兰大在他们的青年（初级和高级 高中活动计划。 该项目进一步促进了VPW计划的目标，即（1）提供 为妇女提供在工程和技术领域发展职业生涯的机会 由NSF支持的科学学科和（2）鼓励妇女 通过提供更大的科学和工程专业知识， 在工业界就业的女科学家和女工程师的知名度， 政府和学术机构。 通过鼓励 妇女参与科学，这是一项宝贵的投资， 国家未来的科学活力。