Multi-User Resource for X-Ray Data Collection at Ambient andCryogenic Temperatures

恢复X射线数据的宝贵仪器资源 三维晶体结构所需的集合 为了实现“最先进”的地位，建议 将现有的单一区域探测器系统升级到 带有电动检测器的传统双检测器配置 测角，并提供数据收集仪器， 低温 对设施的这些修改将 大大加强其在广泛的项目中的使用， 蛋白质结构-功能关系领域，包括 参与的酶的结构测定和分析 蛋白质合成（翻译）和中间代谢， 血红蛋白中的协同作用机制， 艾滋病毒和呼吸氧运输。

To restore a valuable instrumental resource for X-ray data collection required for three-dimensional crystal structure determination to "state-of-the-art" status, it is proposed to upgrade an existing, single area detector system to the conventional dual-detector configuration with motorized detector goniometry, and to provide instrumentation for data collection at cryogenic temperatures. These modifications to the facility will greatly enhance its use in a broad spectrum of projects in the area of protein structure-function relationships, including structure determinations and analyses of enzymes involved in protein synthesis (translation) and intermediary metabolism, the mechanism of cooperativity in hemoglobin, gene products from the AIDS virus, and respiratory oxygen transport.