课题基金 / 基金详情

Multi-User Resource for X-Ray Data Collection at Ambient andCryogenic Temperatures

Multi-User Resource for X-Ray Data Collection at Ambient andCryogenic Temperatures
用于在环境温度和低温下收集 X 射线数据的多用户资源
批准号:
8903850
负责人:
Charles Carter
金额:
$1.69万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-12-01 至 1992-05-31

项目摘要

项目成果

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中文摘要
翻译
为了将三维晶体结构测定所需的x射线数据收集的宝贵仪器资源恢复到“最先进”的状态,建议将现有的单区域探测器系统升级为传统的双探测器配置,并配备电动探测器测角仪。并为低温下的数据收集提供仪器。对该设施的这些改进将大大提高其在蛋白质结构-功能关系领域的广泛项目中的用途,包括结构确定和分析参与蛋白质合成(翻译)和中间代谢的酶、血红蛋白协同作用机制、艾滋病病毒基因产物和呼吸氧运输。
英文摘要
To restore a valuable instrumental resource for X-ray data collection required for three-dimensional crystal structure determination to "state-of-the-art" status, it is proposed to upgrade an existing, single area detector system to the conventional dual-detector configuration with motorized detector goniometry, and to provide instrumentation for data collection at cryogenic temperatures. These modifications to the facility will greatly enhance its use in a broad spectrum of projects in the area of protein structure-function relationships, including structure determinations and analyses of enzymes involved in protein synthesis (translation) and intermediary metabolism, the mechanism of cooperativity in hemoglobin, gene products from the AIDS virus, and respiratory oxygen transport.
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会议论文
Gordon Research Conference: Diffraction Methods in Molecular Biology, June 16 - 21, 1996, at Proctor Academy, Andover, NH
  • 批准号:
    9612746
  • 项目类别:
    Standard Grant
  • 资助金额:
    $0.5万
  • 财政年份:
    1996
  • 负责人:
    Charles Carter
  • 依托单位:
Bayesian Methods for Macromolecular Phase Determination
US-France Cooperative Research: New X-ray Techniques to Study Ligation State Changes in Aminoacyl-tRNA Synthetases
Workshop on a Data Base for Undergraduate Science, Engineer-ing and Mathematics Education
海外基金