Purchase of a Multinuclear 500 MHz NMR Spectrometer

核磁共振波谱是化学家用来阐明分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家和生物学家来说，接触最先进的核磁共振波谱是必不可少的。南卡罗来纳大学哥伦比亚分校化学系将利用化学仪器计划和仪器和仪器开发计划授予的这一奖项，帮助获得高场核磁共振光谱仪。此次收购将加强的研究领域包括：1)第14族有机金属化合物的多核磁共振研究2)天然产物的合成3)细胞色素P-450-CAM与樟脑衍生物的相互作用4)选定的二元和三元构象动力学胸苷合成酶复合体5)质子自旋晶格驰豫时间的研究作为区分过渡金属氢化物中经典和非经典结构的决定性方法6)大环的合成。

Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to the chemist for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectroscopy is essential to chemists and biologists who are carrying out frontier research. The Department of Chemistry at the University of South Carolina at Columbia will use this award from the Chemical Instrumentation Program and the Instrumentation and Instrument Development Program to help acquire a high-field NMR spectrometer. The areas of research that will be enhanced by the acquisition include: 1) Multinuclear magnetic resonance studies of Group 14 organometallic compounds 2) Synthesis of natural products 3) Interactions between cytochrome P-450-CAM and camphor derivatives 4) Conformational dynamics of selected binary and ternary complexes of thymidylate synthase 5) Studies of proton spin lattice relaxation times as a definitive method of distinguishing classical from nonclassical structures in transition-metal hydrides 6) Synthesis of macrocycles.