Genome evolution & adaptation of the multinuclear wheat stripe rust fungus

基因组进化

• 批准号: DP230100941
• 负责人: A/Prof Benjamin Schwessinger
• 金额: $ 31.56万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100941
• 关键词: Genome; evolution; adaptation; multinuclear; wheat

Animals and plants package their genomes into a single nucleus within each cell. In contrast, millions of fungal species accommodate multiple nuclei containing individual haploid genomes. It is currently unknown what the evolutionary implications are for this unusual genome division into multiple nuclei. Here we explore the evolutionary consequences of genome division into multiple nuclei for the first time by applying cutting edge genome biology tools and algorithms. The economically significant study system is the devastating wheat stripe rust fungus. This pathogen costs Australian farmers over $100 million a year. New understanding is expected to lead to better disease management, reduced fungicide applications, and increased yields.

动物和植物将它们的基因组包装成每个细胞内的单个细胞核。相比之下，数百万真菌物种容纳含有单个单倍体基因组的多个细胞核。目前还不清楚这种不寻常的基因组分裂成多个细胞核的进化意义是什么。在这里，我们探索的进化后果的基因组分裂成多个细胞核的第一次应用尖端的基因组生物学工具和算法。具有经济意义的研究体系是小麦条锈菌的毁灭性研究。这种病原体每年给澳大利亚农民造成1亿多美元的损失。新的认识预计将导致更好的疾病管理，减少杀真菌剂的应用，并增加产量。