Research Initiation: Transport Phenomena in Viscous Microbial Broths

研究启动：粘性微生物培养液中的传输现象

• 批准号: 8908454
• 负责人: Timothy Oolman
• 金额: $ 7万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1992-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8908454&HistoricalAwards=false
• 关键词: Research; Initiation; Transport; Phenomena; Viscous

The dynamic flow behavior of viscous microbial broths will be correlated with transport phenomena in mechanically agitated, air-sparged fermenters. Special attention will be given to oxygen transport in broth containing organisms that grow in a mycelial morphology. It is hypothesized that mass transfer correlations based on assumptions of Newtonian behavior are inadequate for correlating mass transfer when the behavior becomes non-newtonian. A critical aspect of developing the engineering base for the emerging biotechnology industry is developing heuristics for scale-up from laboratory or pilot-scale equipment to production-scale equipment. The engineer's ability to make the scale-up accurately depends upon the use of accurate predictions of the behavior of the equipment. This project will determine if alternate correlations are needed as the flow behavior becomes more complex.

粘性微生物培养液的动态流动行为将是 与机械搅拌中的传输现象相关， 充气发酵罐 将特别注意 含有在培养基中生长的生物体的肉汤中的氧气输送 菌丝形态 据推测，传质 基于牛顿行为假设的相关性是 不足以关联传质时， 变成非牛顿的。 发展工程基础的一个关键方面是 新兴的生物技术产业正在发展生物技术， 从实验室或中试规模的设备扩大到 生产规模的设备。 工程师的能力，使 准确地按比例放大取决于使用准确的预测 设备的行为。 该项目将确定如果 随着流动行为变得，需要替代相关性 更加复杂。